See the published version of this preprint at Trials.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Study protocol
Takahiro Mihara
Yokohama Shiritsu Daigaku Fuzoku Byoin
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0613-511X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Appropriate pain management is essential to improve the postoperative recovery after total hip arthroplasty (THA). Various case reports have indicated that anterior quadratus lumborum block (QLB) provides effective postoperative analgesia in lower limb surgeries. However, there are few randomized controlled trials that have confirmed the efficacy of anterior QLB for lower limb surgeries. The aim of this single-center, double-blind, randomized controlled trial is to confirm the efficacy of anterior QLB for postoperative recovery after THA. Methods: The participants will be randomized to either the anterior QLB or placebo groups, using a set of random numbers for the allocation sequence. Only pharmacists will be aware of the allocations; other investigators will be blinded until study completion. After induction of general anesthesia, anterior QLB will be performed using 0.25% levobupivacaine or normal saline. Fentanyl will be administered according to blood pressure change during the surgery. The primary outcome will be the quality of recovery 40 score (QoR-40). Secondary outcomes will include the visual analog scale (VAS) score of pain intensity at rest and movement, intraoperative and postoperative doses of fentanyl, and incidence of postoperative nausea and vomiting. Statistical analysis will be performed using the Student’s t-test, Mann–Whitney U-test, and Fisher’s exact test as appropriate. A p < 0.05 will be considered statistically significant. Discussion: The results of our study will reveal whether anterior QLB is effective for postoperative recovery after THA. Trial registration: UMIN Clinical Trials Registry, UMIN000032255. Registered on 15 April 2018.
Keywords: anterior quadratus lumborum block, hip osteoarthritis, peripheral nerve block, postoperative pain, regional anesthesia, total hip arthroplasty
Keywords
anterior quadratus lumborum block, hip osteoarthritis, peripheral nerve block, postoperative pain, regional anesthesia, total hip arthroplasty
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Trials.
Version 2
Posted 09 Jan, 2020
No community comments so far
Editorial decision: Accept
On 18 Jan, 2020
Review #2 received
Received 16 Jan, 2020
Reviewers invited
Invitations sent on 13 Jan, 2020
Reviewer #1 agreed
On 13 Jan, 2020
Reviewer #2 agreed
On 13 Jan, 2020
Review #1 received
Received 13 Jan, 2020
Editor assigned
On 06 Jan, 2020
Submission checks complete
On 05 Jan, 2020
No comments provided
Editorial decision: Major revision
On 12 Dec, 2019
Review #6 received
Received 03 Dec, 2019
Review #5 received
Received 02 Dec, 2019
Review #4 received
Received 02 Dec, 2019
Review #3 received
Received 29 Nov, 2019
Review #1 received
Received 26 Nov, 2019
Review #2 received
Received 19 Nov, 2019
Reviewer #6 agreed
On 19 Nov, 2019
Reviewer #2 agreed
On 18 Nov, 2019
Reviewer #3 agreed
On 18 Nov, 2019
Reviewer #4 agreed
On 18 Nov, 2019
Reviewer #5 agreed
On 18 Nov, 2019
Reviewer #1 agreed
On 17 Nov, 2019
Reviewers invited
Invitations sent on 07 Nov, 2019
Editor assigned
On 27 Aug, 2019
First submitted
On 31 Jul, 2019
Submission checks complete
On 31 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Integrative & Complementary Medicine
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Trials.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Study protocol
Takahiro Mihara
Yokohama Shiritsu Daigaku Fuzoku Byoin
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0613-511X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Trials.
Version 2
Posted 09 Jan, 2020
No community comments so far
Editorial decision: Accept
On 18 Jan, 2020
Review #2 received
Received 16 Jan, 2020
Reviewers invited
Invitations sent on 13 Jan, 2020
Reviewer #1 agreed
On 13 Jan, 2020
Reviewer #2 agreed
On 13 Jan, 2020
Review #1 received
Received 13 Jan, 2020
Editor assigned
On 06 Jan, 2020
Submission checks complete
On 05 Jan, 2020
No comments provided
Editorial decision: Major revision
On 12 Dec, 2019
Review #6 received
Received 03 Dec, 2019
Review #5 received
Received 02 Dec, 2019
Review #4 received
Received 02 Dec, 2019
Review #3 received
Received 29 Nov, 2019
Review #1 received
Received 26 Nov, 2019
Review #2 received
Received 19 Nov, 2019
Reviewer #6 agreed
On 19 Nov, 2019
Reviewer #2 agreed
On 18 Nov, 2019
Reviewer #3 agreed
On 18 Nov, 2019
Reviewer #4 agreed
On 18 Nov, 2019
Reviewer #5 agreed
On 18 Nov, 2019
Reviewer #1 agreed
On 17 Nov, 2019
Reviewers invited
Invitations sent on 07 Nov, 2019
Editor assigned
On 27 Aug, 2019
First submitted
On 31 Jul, 2019
Submission checks complete
On 31 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Integrative & Complementary Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Trials.
Background: Appropriate pain management is essential to improve the postoperative recovery after total hip arthroplasty (THA). Various case reports have indicated that anterior quadratus lumborum block (QLB) provides effective postoperative analgesia in lower limb surgeries. However, there are few randomized controlled trials that have confirmed the efficacy of anterior QLB for lower limb surgeries. The aim of this single-center, double-blind, randomized controlled trial is to confirm the efficacy of anterior QLB for postoperative recovery after THA. Methods: The participants will be randomized to either the anterior QLB or placebo groups, using a set of random numbers for the allocation sequence. Only pharmacists will be aware of the allocations; other investigators will be blinded until study completion. After induction of general anesthesia, anterior QLB will be performed using 0.25% levobupivacaine or normal saline. Fentanyl will be administered according to blood pressure change during the surgery. The primary outcome will be the quality of recovery 40 score (QoR-40). Secondary outcomes will include the visual analog scale (VAS) score of pain intensity at rest and movement, intraoperative and postoperative doses of fentanyl, and incidence of postoperative nausea and vomiting. Statistical analysis will be performed using the Student’s t-test, Mann–Whitney U-test, and Fisher’s exact test as appropriate. A p < 0.05 will be considered statistically significant. Discussion: The results of our study will reveal whether anterior QLB is effective for postoperative recovery after THA. Trial registration: UMIN Clinical Trials Registry, UMIN000032255. Registered on 15 April 2018.
Keywords: anterior quadratus lumborum block, hip osteoarthritis, peripheral nerve block, postoperative pain, regional anesthesia, total hip arthroplasty
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
Loading...