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Research
Juan Ignacio Arraras
Complejo Hospitalario de Navarra. Irunlarrea
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4415-2570
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
General population normative data for the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aimed to present normative data of the Spanish general population.
Methods/Patients
Data were obtained from a prior larger study collecting EORTC QLQ-C30 norm data across 15 countries. Data were stratified by sex and age groups (18–39, 40–49, 50–59, 60–69 and >70 years). Sex and age distribution were weighted according to population distribution statistics. Sex- and age-specific normative values were analysed separately, as were participants with versus those without health conditions. Multiple linear regression was used to estimate the association of each of the EORTC QLQ-C30 scales with the determinants age, sex, sex-by-age interaction term, and health condition.
Results
1165 Spanish individuals participated in the study. Differences were found by sex and age. The largest sex-related differences were seen in fatigue, emotional functioning, and global QoL (Quality of Life), favouring men. Largest age differences were seen in emotional functioning, insomnia, and pain, with middle-aged groups having the worst scores. Those >60 years scored better than those <60 years on all scales except for physical functioning. Participants with no health conditions scored better in all QLQ-C30 domains.
Conclusions
The present study highlights differences in HRQoL between specific sex/age strata and especially between persons with and without a health condition in the Spanish general population. These factors must be considered when comparing general population HRQoL data with that of cancer patients.
Keywords
EORTC QLQ-C30, normative values, Spain, general population, questionnaire, quality of life
This is a list of supplementary files associated with this preprint. Click to download.
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CURRENT STATUS: Under Review
Version 1
Posted 23 Mar, 2021
No community comments so far
Review #3 received
Received 11 Apr, 2021
Editorial decision: Minor Revision
On 11 Apr, 2021
Review #1 received
Received 10 Apr, 2021
Review #2 received
Received 06 Apr, 2021
Reviewer #3 agreed
On 29 Mar, 2021
Reviewer #2 agreed
On 26 Mar, 2021
Reviews received
Received 26 Mar, 2021
Reviewer #1 agreed
On 25 Mar, 2021
Reviewers invited
Invitations sent on 22 Mar, 2021
Editor assigned
On 14 Mar, 2021
Submission checks complete
On 14 Mar, 2021
Editor invited
On 14 Mar, 2021
First submitted
On 12 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Health Economics & Outcomes Research
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Health and Quality of Life Outcomes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Juan Ignacio Arraras
Complejo Hospitalario de Navarra. Irunlarrea
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4415-2570
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 23 Mar, 2021
No community comments so far
Review #3 received
Received 11 Apr, 2021
Editorial decision: Minor Revision
On 11 Apr, 2021
Review #1 received
Received 10 Apr, 2021
Review #2 received
Received 06 Apr, 2021
Reviewer #3 agreed
On 29 Mar, 2021
Reviewer #2 agreed
On 26 Mar, 2021
Reviews received
Received 26 Mar, 2021
Reviewer #1 agreed
On 25 Mar, 2021
Reviewers invited
Invitations sent on 22 Mar, 2021
Editor assigned
On 14 Mar, 2021
Submission checks complete
On 14 Mar, 2021
Editor invited
On 14 Mar, 2021
First submitted
On 12 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Health Economics & Outcomes Research
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
General population normative data for the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aimed to present normative data of the Spanish general population.
Methods/Patients
Data were obtained from a prior larger study collecting EORTC QLQ-C30 norm data across 15 countries. Data were stratified by sex and age groups (18–39, 40–49, 50–59, 60–69 and >70 years). Sex and age distribution were weighted according to population distribution statistics. Sex- and age-specific normative values were analysed separately, as were participants with versus those without health conditions. Multiple linear regression was used to estimate the association of each of the EORTC QLQ-C30 scales with the determinants age, sex, sex-by-age interaction term, and health condition.
Results
1165 Spanish individuals participated in the study. Differences were found by sex and age. The largest sex-related differences were seen in fatigue, emotional functioning, and global QoL (Quality of Life), favouring men. Largest age differences were seen in emotional functioning, insomnia, and pain, with middle-aged groups having the worst scores. Those >60 years scored better than those <60 years on all scales except for physical functioning. Participants with no health conditions scored better in all QLQ-C30 domains.
Conclusions
The present study highlights differences in HRQoL between specific sex/age strata and especially between persons with and without a health condition in the Spanish general population. These factors must be considered when comparing general population HRQoL data with that of cancer patients.
This is a list of supplementary files associated with this preprint. Click to download.
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