This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Gaojun Cai
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4250-180X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: The present research was carried out to explore the correlation between high-density lipoprotein cholesterol (HDL-C)/ apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD).
Methods: A total of 1,686 patients underwent selective coronary angiography, including 1,279 CAD patients and 407 controls were enrolled in the present study. The subjects were divided into three groups according to tertiles of HDL-C/apoA-I. Binary logistic regression analysis was used to evaluate the interaction of HDL-C/apoA-I and FT3 on the risk of CAD.
Results: The group with highest HDL-C/apoA-I had the lowest FT3 levels. Multiple linear regression analysis showed that HDL-C/apoA-I were negatively associated with FT3 after adjusting age, sex, body mass index (BMI), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoproteinB (ApoB). Logistic regression model showed that high HDL-C/apoA-I (>0.89mmol/g) and high FT3 level (>4.5pmol/l) were protective factor for CAD. Patients with the lower HDL-C/ apoA-I (≤0.89mmol/g) and FT3 level (≤4.5pmol/l) have an increased risk of CAD (OR =2.441, P=0.000, S =1.13, AP=0.068, AP* = 0.116, RERI=0.168).
Conclusions: Lower HDL-C/ apoA-I was risk factor for CAD and there was a positive interaction between HDL-C/ apoA-I and FT3 on the risk of CAD.
Keywords
coronary artery disease, free triiodothyronine, high-density lipoprotein cholesterol/ apolipoprotein A-I
Figure 1
Figure 2
Figure 3
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Gaojun Cai
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4250-180X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: The present research was carried out to explore the correlation between high-density lipoprotein cholesterol (HDL-C)/ apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD).
Methods: A total of 1,686 patients underwent selective coronary angiography, including 1,279 CAD patients and 407 controls were enrolled in the present study. The subjects were divided into three groups according to tertiles of HDL-C/apoA-I. Binary logistic regression analysis was used to evaluate the interaction of HDL-C/apoA-I and FT3 on the risk of CAD.
Results: The group with highest HDL-C/apoA-I had the lowest FT3 levels. Multiple linear regression analysis showed that HDL-C/apoA-I were negatively associated with FT3 after adjusting age, sex, body mass index (BMI), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoproteinB (ApoB). Logistic regression model showed that high HDL-C/apoA-I (>0.89mmol/g) and high FT3 level (>4.5pmol/l) were protective factor for CAD. Patients with the lower HDL-C/ apoA-I (≤0.89mmol/g) and FT3 level (≤4.5pmol/l) have an increased risk of CAD (OR =2.441, P=0.000, S =1.13, AP=0.068, AP* = 0.116, RERI=0.168).
Conclusions: Lower HDL-C/ apoA-I was risk factor for CAD and there was a positive interaction between HDL-C/ apoA-I and FT3 on the risk of CAD.
Figure 1
Figure 2
Figure 3
Loading...