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Research article
Qun Hu
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1508-2796
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Background: No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters.
Methods: This study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th –97.5th percentiles.
Results: Capillary reference interval for platelet count was (152 - 464) ×109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37-41 weeks) and postnatal age (12-84 hours). Reference intervals for other platelet parameters were affected by these factors to a different extent.
Conclusions: We established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China.
Keywords
Neonates, Capillary blood, Platelet count, Platelet parameters, Reference intervals
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CURRENT STATUS: Published
View the published article at BMC Pediatrics.
Version 2
Posted 13 Oct, 2020
No community comments so far
Submission checks complete
On 05 Oct, 2020
Editorial decision: Accept
On 01 Oct, 2020
No comments provided
Editorial decision: Major revision
On 20 Jul, 2020
Reviewer #2 agreed
On 03 Jul, 2020
Review #2 received
Received 03 Jul, 2020
Review #3 received
Received 03 Jul, 2020
Reviewer #3 agreed
On 03 Jul, 2020
Review #1 received
Received 28 Jun, 2020
Reviewers invited
Invitations sent on 21 Jun, 2020
Reviewer #1 agreed
On 21 Jun, 2020
Editor assigned
On 02 Jun, 2020
First submitted
On 01 Jun, 2020
Submission checks complete
On 01 Jun, 2020
Editor invited
On 01 Jun, 2020
Version (no preprint)
Posted 08 Jun, 2020
Editorial decision: Minor revision
On 25 Sep, 2020
Reviewers invited
Invitations sent on 04 Aug, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
This version was not preprinted
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Pediatrics
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A new preprint design is coming!
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See the published version of this preprint at BMC Pediatrics.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Qun Hu
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1508-2796
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pediatrics.
Version 2
Posted 13 Oct, 2020
No community comments so far
Submission checks complete
On 05 Oct, 2020
Editorial decision: Accept
On 01 Oct, 2020
No comments provided
Editorial decision: Major revision
On 20 Jul, 2020
Reviewer #2 agreed
On 03 Jul, 2020
Review #2 received
Received 03 Jul, 2020
Review #3 received
Received 03 Jul, 2020
Reviewer #3 agreed
On 03 Jul, 2020
Review #1 received
Received 28 Jun, 2020
Reviewers invited
Invitations sent on 21 Jun, 2020
Reviewer #1 agreed
On 21 Jun, 2020
Editor assigned
On 02 Jun, 2020
First submitted
On 01 Jun, 2020
Submission checks complete
On 01 Jun, 2020
Editor invited
On 01 Jun, 2020
Version (no preprint)
Posted 08 Jun, 2020
Editorial decision: Minor revision
On 25 Sep, 2020
Reviewers invited
Invitations sent on 04 Aug, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
This version was not preprinted
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pediatrics.
Background: No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters.
Methods: This study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th –97.5th percentiles.
Results: Capillary reference interval for platelet count was (152 - 464) ×109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37-41 weeks) and postnatal age (12-84 hours). Reference intervals for other platelet parameters were affected by these factors to a different extent.
Conclusions: We established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China.
Figure 1
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