This preprint is under consideration at BMC Microbiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
zahra Arab-Bafrani
Golestan University of Medical Sciences and Health Services School of Health and Paramedicine
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The widespread outbreak of SARS-CoV-2 has become a deal threat for human health. This new emerged virus coupled with severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS) viruses belong to coronoviridae family, which develop SARS in human being. However, prior to the emergence of virulent viruses, the coronaviruses were known as the leading causes of mild common cold. Getting more knowledge about the genome organization of different strains can conduct us how these viruses evolve and become a virulent strain. Here, we reported the difference of oligonucleotide distribution contributing in genome of two groups of coronaviruses, SARS related viruses versa common cold coronaviruses, by employing weighting algorithms approaches.
Results: In this study, we found a few oligonucleotides, which significantly distinguish two viral groups. Among dinucleotide’s features, the discrepancy of TC and CC between SARS related viruses and common cold coronaviruses was quite considerable. Furthermore, CC dinucleotide was sequentially repeated in a few multinucleotide patterns including CCA, CCAC, ACCAC, and CACCAC motifs with the highest values, which also discriminated two viral groups.
Conclusions: Theses remarkable oligonucleotides might point towards the existence of some particular RNA elements that might be involved in viral infectivity.
Keywords
SARS-CoV-2, MERS, SARS, Common cold coronaviruses, Oligonucleotide patterns, viral genome
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Mar, 2021
No community comments so far
Editor assigned
On 10 Mar, 2021
Submission checks complete
On 10 Mar, 2021
Editor invited
On 10 Mar, 2021
First submitted
On 04 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Microbiology
Learn more about our company.
This preprint is under consideration at BMC Microbiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
zahra Arab-Bafrani
Golestan University of Medical Sciences and Health Services School of Health and Paramedicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Mar, 2021
No community comments so far
Editor assigned
On 10 Mar, 2021
Submission checks complete
On 10 Mar, 2021
Editor invited
On 10 Mar, 2021
First submitted
On 04 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Microbiology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The widespread outbreak of SARS-CoV-2 has become a deal threat for human health. This new emerged virus coupled with severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS) viruses belong to coronoviridae family, which develop SARS in human being. However, prior to the emergence of virulent viruses, the coronaviruses were known as the leading causes of mild common cold. Getting more knowledge about the genome organization of different strains can conduct us how these viruses evolve and become a virulent strain. Here, we reported the difference of oligonucleotide distribution contributing in genome of two groups of coronaviruses, SARS related viruses versa common cold coronaviruses, by employing weighting algorithms approaches.
Results: In this study, we found a few oligonucleotides, which significantly distinguish two viral groups. Among dinucleotide’s features, the discrepancy of TC and CC between SARS related viruses and common cold coronaviruses was quite considerable. Furthermore, CC dinucleotide was sequentially repeated in a few multinucleotide patterns including CCA, CCAC, ACCAC, and CACCAC motifs with the highest values, which also discriminated two viral groups.
Conclusions: Theses remarkable oligonucleotides might point towards the existence of some particular RNA elements that might be involved in viral infectivity.
Figure 1
Figure 2
Figure 3
Loading...