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Case report
Ikuya Miyamoto
Iwate Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4642-8611
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer. Here we report a rare case involving an elderly man with a primary epithelioid angiosarcoma that originated from the mandibular gingiva and resembled a dentigerous cyst on radiographs.
Case presentation
A 66-year-old Japanese man visited our hospital with a chief complaint of gingival swelling in right mandibular third molar region. A panoramic radiograph showed bone resorption around the crown of right mandibular third molar, which was impacted. Incisional biopsy confirmed a diagnosis of epithelioid angiosarcoma. The lesion exhibited aggressive proliferation after biopsy resulting in uncontrolled bleeding and difficulty in closing the mouth. Mandibular segmental resection including the tumor was performed without reconstruction. Because of the aggressive preoperative course of the tumor, the patient received adjuvant chemotherapy. There were no signs of recurrence during a 1-year follow-up period.
Conclusions
A review of the literature yielded only three reported cases of epithelioid angiosarcoma in the jaw region, with the lesions occurring in the maxilla in all three cases. To our knowledge, this is the first case of primary epithelioid angiosarcoma in the mandible.
Keywords
epithelioid angiosarcoma, mandibular gingiva, vascular tumor
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at World Journal of Surgical Oncology.
No community comments so far
Editorial decision: Accept
On 10 Aug, 2020
Review #1 received
Received 03 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Editor assigned
On 22 Jul, 2020
Reviewers invited
Invitations sent on 22 Jul, 2020
Submission checks complete
On 21 Jul, 2020
Editor invited
On 21 Jul, 2020
Version 1
Posted 05 Jun, 2020
No comments provided
Reviewer #2 agreed
On 06 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Editorial decision: Major Revision
On 06 Jul, 2020
Review #1 received
Received 30 Jun, 2020
Reviewer #1 agreed
On 15 Jun, 2020
Reviewers invited
Invitations sent on 03 Jun, 2020
First submitted
On 02 Jun, 2020
Editor assigned
On 02 Jun, 2020
Submission checks complete
On 01 Jun, 2020
Editor invited
On 01 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at World Journal of Surgical Oncology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
Ikuya Miyamoto
Iwate Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4642-8611
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at World Journal of Surgical Oncology.
No community comments so far
Editorial decision: Accept
On 10 Aug, 2020
Review #1 received
Received 03 Aug, 2020
Reviewer #1 agreed
On 24 Jul, 2020
Editor assigned
On 22 Jul, 2020
Reviewers invited
Invitations sent on 22 Jul, 2020
Submission checks complete
On 21 Jul, 2020
Editor invited
On 21 Jul, 2020
Version 1
Posted 05 Jun, 2020
No comments provided
Reviewer #2 agreed
On 06 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Editorial decision: Major Revision
On 06 Jul, 2020
Review #1 received
Received 30 Jun, 2020
Reviewer #1 agreed
On 15 Jun, 2020
Reviewers invited
Invitations sent on 03 Jun, 2020
First submitted
On 02 Jun, 2020
Editor assigned
On 02 Jun, 2020
Submission checks complete
On 01 Jun, 2020
Editor invited
On 01 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at World Journal of Surgical Oncology.
Background
Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer. Here we report a rare case involving an elderly man with a primary epithelioid angiosarcoma that originated from the mandibular gingiva and resembled a dentigerous cyst on radiographs.
Case presentation
A 66-year-old Japanese man visited our hospital with a chief complaint of gingival swelling in right mandibular third molar region. A panoramic radiograph showed bone resorption around the crown of right mandibular third molar, which was impacted. Incisional biopsy confirmed a diagnosis of epithelioid angiosarcoma. The lesion exhibited aggressive proliferation after biopsy resulting in uncontrolled bleeding and difficulty in closing the mouth. Mandibular segmental resection including the tumor was performed without reconstruction. Because of the aggressive preoperative course of the tumor, the patient received adjuvant chemotherapy. There were no signs of recurrence during a 1-year follow-up period.
Conclusions
A review of the literature yielded only three reported cases of epithelioid angiosarcoma in the jaw region, with the lesions occurring in the maxilla in all three cases. To our knowledge, this is the first case of primary epithelioid angiosarcoma in the mandible.
Figure 1
Figure 2
Figure 3
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