See the published version of this preprint at Journal of Nanobiotechnology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research
haimin chen
Guangxi Medical University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal−organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as [email protected]@PCA, for the therapy of OA. Results demonstrated that [email protected]@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. [email protected]@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.
Keywords
Osteoarthritis, pH-responsive, metal-organic frameworks, protocatechuic acid
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Journal of Nanobiotechnology.
No community comments so far
Editorial decision: Accept
On 31 Aug, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
Version 1
Posted 09 Jun, 2020
No comments provided
Editorial decision: Major revision
On 28 Jun, 2020
Review #2 received
Received 24 Jun, 2020
Review #1 received
Received 24 Jun, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Reviewer #1 agreed
On 16 Jun, 2020
Reviewer #2 agreed
On 16 Jun, 2020
Editor assigned
On 06 Jun, 2020
First submitted
On 05 Jun, 2020
Submission checks complete
On 05 Jun, 2020
Editor invited
On 05 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Journal of Nanobiotechnology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
haimin chen
Guangxi Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Journal of Nanobiotechnology.
No community comments so far
Editorial decision: Accept
On 31 Aug, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
Version 1
Posted 09 Jun, 2020
No comments provided
Editorial decision: Major revision
On 28 Jun, 2020
Review #2 received
Received 24 Jun, 2020
Review #1 received
Received 24 Jun, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Reviewer #1 agreed
On 16 Jun, 2020
Reviewer #2 agreed
On 16 Jun, 2020
Editor assigned
On 06 Jun, 2020
First submitted
On 05 Jun, 2020
Submission checks complete
On 05 Jun, 2020
Editor invited
On 05 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Nanobiotechnology.
Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal−organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as [email protected]@PCA, for the therapy of OA. Results demonstrated that [email protected]@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. [email protected]@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Loading...