Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation
Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO).
Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion.
Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851,P<0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%.
Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.
Figure 1
Figure 2
Posted 15 Apr, 2020
On 08 Jul, 2020
On 21 May, 2020
On 13 Apr, 2020
On 12 Apr, 2020
On 12 Apr, 2020
On 06 Apr, 2020
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Received 16 Oct, 2019
Received 04 Oct, 2019
Invitations sent on 04 Oct, 2019
On 04 Oct, 2019
On 04 Oct, 2019
On 01 Oct, 2019
On 30 Sep, 2019
On 30 Sep, 2019
On 07 Sep, 2019
Received 27 Aug, 2019
Invitations sent on 09 Aug, 2019
On 09 Aug, 2019
On 02 Aug, 2019
On 26 Jul, 2019
On 25 Jul, 2019
On 24 Jul, 2019
Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation
Posted 15 Apr, 2020
On 08 Jul, 2020
On 21 May, 2020
On 13 Apr, 2020
On 12 Apr, 2020
On 12 Apr, 2020
On 06 Apr, 2020
On 10 Mar, 2020
On 09 Mar, 2020
On 09 Mar, 2020
On 11 Feb, 2020
On 18 Jan, 2020
Received 16 Oct, 2019
Received 04 Oct, 2019
Invitations sent on 04 Oct, 2019
On 04 Oct, 2019
On 04 Oct, 2019
On 01 Oct, 2019
On 30 Sep, 2019
On 30 Sep, 2019
On 07 Sep, 2019
Received 27 Aug, 2019
Invitations sent on 09 Aug, 2019
On 09 Aug, 2019
On 02 Aug, 2019
On 26 Jul, 2019
On 25 Jul, 2019
On 24 Jul, 2019
Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO).
Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion.
Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851,P<0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%.
Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.
Figure 1
Figure 2