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Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation
Zhiquan Wang
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0848-4471
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cardiovascular Disorders.
Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO).
Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion.
Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%.
Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.
Keywords
Coronary artery disease;Chronic total occlusion;Collateral circulation;Ischemia modified albumin
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CURRENT STATUS: Published
Version 4
Posted 15 Apr, 2020
Published
On 08 Jul, 2020
No community comments so far
Editorial decision: Accept
On 21 May, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 12 Apr, 2020
Editor invited
On 12 Apr, 2020
No comments provided
Editorial decision: Major revision
On 06 Apr, 2020
Editor assigned
On 10 Mar, 2020
Submission checks complete
On 09 Mar, 2020
Editor invited
On 09 Mar, 2020
No comments provided
Editorial decision: Major revision
On 11 Feb, 2020
Reviewer #3 agreed
On 18 Jan, 2020
Review #2 received
Received 16 Oct, 2019
Review #1 received
Received 04 Oct, 2019
Reviewers invited
Invitations sent on 04 Oct, 2019
Reviewer #1 agreed
On 04 Oct, 2019
Reviewer #2 agreed
On 04 Oct, 2019
Editor assigned
On 01 Oct, 2019
Submission checks complete
On 30 Sep, 2019
Editor invited
On 30 Sep, 2019
No comments provided
Editorial decision: Major revision
On 07 Sep, 2019
Review #1 received
Received 27 Aug, 2019
Reviewers invited
Invitations sent on 09 Aug, 2019
Reviewer #1 agreed
On 09 Aug, 2019
Submission checks complete
On 02 Aug, 2019
Editor assigned
On 26 Jul, 2019
Editor invited
On 25 Jul, 2019
First submitted
On 24 Jul, 2019
Metrics
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Subject Areas
Cardiac & Cardiovascular Systems
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This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation
Zhiquan Wang
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0848-4471
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 4
Posted 15 Apr, 2020
Published
On 08 Jul, 2020
No community comments so far
Editorial decision: Accept
On 21 May, 2020
Editor assigned
On 13 Apr, 2020
Submission checks complete
On 12 Apr, 2020
Editor invited
On 12 Apr, 2020
No comments provided
Editorial decision: Major revision
On 06 Apr, 2020
Editor assigned
On 10 Mar, 2020
Submission checks complete
On 09 Mar, 2020
Editor invited
On 09 Mar, 2020
No comments provided
Editorial decision: Major revision
On 11 Feb, 2020
Reviewer #3 agreed
On 18 Jan, 2020
Review #2 received
Received 16 Oct, 2019
Review #1 received
Received 04 Oct, 2019
Reviewers invited
Invitations sent on 04 Oct, 2019
Reviewer #1 agreed
On 04 Oct, 2019
Reviewer #2 agreed
On 04 Oct, 2019
Editor assigned
On 01 Oct, 2019
Submission checks complete
On 30 Sep, 2019
Editor invited
On 30 Sep, 2019
No comments provided
Editorial decision: Major revision
On 07 Sep, 2019
Review #1 received
Received 27 Aug, 2019
Reviewers invited
Invitations sent on 09 Aug, 2019
Reviewer #1 agreed
On 09 Aug, 2019
Submission checks complete
On 02 Aug, 2019
Editor assigned
On 26 Jul, 2019
Editor invited
On 25 Jul, 2019
First submitted
On 24 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cardiovascular Disorders.
Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO).
Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion.
Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%.
Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.
Figure 1
Figure 2