Can 68Ga-prostate specific membrane antigen positron emission tomography / computerized tomography provide an accurate lymph node staging for patients with medium / high risk prostate cancer? A Diagnostic Meta-Analysis
Objective: This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a meta-analysis of diagnostic tests.
Methods: We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 was used for calculation and statistical analyses.
Results: Sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CI) be used to evaluate the diagnostic value. A total of 10 studies were included in our meta-analysis, which included 701 individuals. The results of each consolidated summary are as follows: sensitivity of 0.84 (95% CI: 0.55-0.95), specificity of 0.95 (95% CI: 0.87-0.98), PLR and NLR was 17.19 (95% CI: 6.27, 47.17) and 0.17 (95% CI: 0.05-0.56), respectively. DOR of 100 (95% CI: 18-545), AUC of 0.97 (95% CI: 0.95-0.98).
Conclusion: Our study demonstrates that 68Ga-PSMA PET/CT has a high overall diagnostic value for LN staging in patients with moderate and high-risk PCa. But our conclusions still require a larger sample size, multi-center prospective randomized controlled trial to verify.
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Posted 22 Sep, 2020
On 01 Oct, 2020
On 23 Sep, 2020
Invitations sent on 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Received 15 Sep, 2020
Received 15 Sep, 2020
On 14 Sep, 2020
On 13 Sep, 2020
On 13 Sep, 2020
Received 06 Aug, 2020
On 06 Aug, 2020
On 18 Jun, 2020
Received 16 Jun, 2020
Invitations sent on 03 Jun, 2020
On 03 Jun, 2020
On 02 Jun, 2020
On 02 Jun, 2020
On 01 Jun, 2020
On 01 Jun, 2020
Can 68Ga-prostate specific membrane antigen positron emission tomography / computerized tomography provide an accurate lymph node staging for patients with medium / high risk prostate cancer? A Diagnostic Meta-Analysis
Posted 22 Sep, 2020
On 01 Oct, 2020
On 23 Sep, 2020
Invitations sent on 15 Sep, 2020
On 15 Sep, 2020
On 15 Sep, 2020
Received 15 Sep, 2020
Received 15 Sep, 2020
On 14 Sep, 2020
On 13 Sep, 2020
On 13 Sep, 2020
Received 06 Aug, 2020
On 06 Aug, 2020
On 18 Jun, 2020
Received 16 Jun, 2020
Invitations sent on 03 Jun, 2020
On 03 Jun, 2020
On 02 Jun, 2020
On 02 Jun, 2020
On 01 Jun, 2020
On 01 Jun, 2020
Objective: This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a meta-analysis of diagnostic tests.
Methods: We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 was used for calculation and statistical analyses.
Results: Sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CI) be used to evaluate the diagnostic value. A total of 10 studies were included in our meta-analysis, which included 701 individuals. The results of each consolidated summary are as follows: sensitivity of 0.84 (95% CI: 0.55-0.95), specificity of 0.95 (95% CI: 0.87-0.98), PLR and NLR was 17.19 (95% CI: 6.27, 47.17) and 0.17 (95% CI: 0.05-0.56), respectively. DOR of 100 (95% CI: 18-545), AUC of 0.97 (95% CI: 0.95-0.98).
Conclusion: Our study demonstrates that 68Ga-PSMA PET/CT has a high overall diagnostic value for LN staging in patients with moderate and high-risk PCa. But our conclusions still require a larger sample size, multi-center prospective randomized controlled trial to verify.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6