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Research article
Serum vitamin D deficiency in NICU hospitalized neonates and its association with neonatal outcomes
Amir Hossein Movahedian
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1266-2007
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Neonates could be strongly affected by vitamin D deficiency-related adverse effects. In the present study, we aimed to determine the prevalence of vitamin D deficiency in the neonatal intensive care unit (NICU) hospitalized neonates and its possible relationship with neonatal outcomes.
Methods: A prospective cross-sectional study was carried out in the NICU of Children's Medical Center (Tehran-Iran; 2015). The population study was NICU hospitalized neonates. Immediately on admission, serum sample for vitamin D measurement was obtained with routine blood sampling. Demographic and clinical data including serum levels of vitamin D and calcium, the causes of hospitalization, and neonatal outcome were recorded. The prevalence of vitamin D deficiency and its association with neonatal outcome were assessed.
Results: One-hundred subjects entered the study. Vitamin D deficiency and insufficiency were present in 95% of neonates. There was a significant association between vitamin D status and season of birth (p=0.014); calcium status (p=0.025) and age at NICU admission (p<0.001). The mean value of vitamin D in term neonates was significantly lower than preterm neonates (p=0.031). There were no correlations between neonatal mortality with vitamin D (p=0.876) status.
Conclusion: Vitamin D deficiency/insufficiency was highly prevalent among our NICU hospitalized neonates. There was no association between vitamin D level and neonatal outcomes. Neonates' vitamin D statuses were significantly correlated with the neonate's age at hospital admission, calcium status and season of birth. The measurement of serum vitamin D along with other routine blood tests in neonates who need NICU admission was strongly recommended.
Keywords
Vitamin D level, Neonate, Neonatal intensive care unit, Outcome
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This is a preprint. It has not completed peer review.
Research article
Serum vitamin D deficiency in NICU hospitalized neonates and its association with neonatal outcomes
Amir Hossein Movahedian
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1266-2007
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 08 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Neonates could be strongly affected by vitamin D deficiency-related adverse effects. In the present study, we aimed to determine the prevalence of vitamin D deficiency in the neonatal intensive care unit (NICU) hospitalized neonates and its possible relationship with neonatal outcomes.
Methods: A prospective cross-sectional study was carried out in the NICU of Children's Medical Center (Tehran-Iran; 2015). The population study was NICU hospitalized neonates. Immediately on admission, serum sample for vitamin D measurement was obtained with routine blood sampling. Demographic and clinical data including serum levels of vitamin D and calcium, the causes of hospitalization, and neonatal outcome were recorded. The prevalence of vitamin D deficiency and its association with neonatal outcome were assessed.
Results: One-hundred subjects entered the study. Vitamin D deficiency and insufficiency were present in 95% of neonates. There was a significant association between vitamin D status and season of birth (p=0.014); calcium status (p=0.025) and age at NICU admission (p<0.001). The mean value of vitamin D in term neonates was significantly lower than preterm neonates (p=0.031). There were no correlations between neonatal mortality with vitamin D (p=0.876) status.
Conclusion: Vitamin D deficiency/insufficiency was highly prevalent among our NICU hospitalized neonates. There was no association between vitamin D level and neonatal outcomes. Neonates' vitamin D statuses were significantly correlated with the neonate's age at hospital admission, calcium status and season of birth. The measurement of serum vitamin D along with other routine blood tests in neonates who need NICU admission was strongly recommended.
Figure 1
Figure 2