Background: Nonalcoholic fatty liver disease (NAFLD), especially with liver fibrosis, is associated with cardiovascular diseases (CVD). NAFLD fibrosis score (NFS), a noninvasive marker of advanced fibrosis first developed in patients with NAFLD, has found to be associated with CVD in different populations including with diabetes, regardless of the presence of NAFLD. The aim of the present study was to determine whether NFS is associated with subclinical myocardial remodeling in type 2 diabetic patients.
Methods: A cross-sectional study was performed in type 2 diabetic patients. NFS derived from available parameters was calculated and the subjects were divided into four groups according to the quartiles of NFS. Subclinical myocardial remodeling was examined by echocardiography and its association with NFS was analyzed.
Results: A total of 1878 type 2 diabetic patients were enrolled in the present study. Subjects with higher NFS were older, had a longer duration of diabetes and higher levels of body mass index (BMI), systolic blood pressure (SBP) and serum creatinine (Scr) than those with lower NFS (P < 0.01). Multiple linear regression analysis revealed that sex, age, BMI, LDL-C and HbA1c were independent determiners of NFS in type 2 diabetic patients. Parameters of subclinical myocardial remodeling including left atrial dimension (LAD), interventricular septum thickness (IST), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular posterior wall thickness (LVPWT) were all gradually increased with the increment of NFS. Linear regression analysis further revealed that NFS was positively associated with LAD, IST, LVEDD, LVESD and LVPWT after adjustment for the confounding factors.
Conclusions: NFS is independently associated with subclinical myocardial remodeling in type 2 diabetic subjects.