This research presents the results of investigation and analysis of the environmentally friendly refrigerant for R22 replacement. All refrigerant properties in this research were based on results from the REFPROP and CYCLE_D-HX software of NIST under CAN/ANSI/AHRI540. The results of this work show that HCs R170, R290, R600, R600a, R601, R601a, R1150 and R1270 can be mixed in HFCs R417A, R417B, R422A, R422B, R422C, R422D, R424A, R437A, R438A and R453A and able to be further developed in the future. All refrigerants are non-flammable refrigerants, non-toxic and zero ODP. The R453A mixed with HCs R600 (0.6%) and R601a (0.6%) and is COPc refrigerant close to that of R22 refrigerant. In conclusion, it can be used as an environmentally friendly and energy efficiency replacement for R22. All refrigerants are also refrigerants that are matched with the 4th generation refrigerants with the use of natural refrigerants.