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Research article
Heart failure as a cause of hospitalization in IPF: comparison of the HFpEF, HFrEF, and PH
Osamu Nishiyama
Kindai University, Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9163-9605
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fibrosing lung disease. Some IPF patients require hospitalization because of heart failure (HF), including HF with preserved ejection fraction (HFpEF), HF with reduced ejection fraction (HFrEF), and HF due to pulmonary hypertension (HFPH). However, the association between IPF and HF has not been clarified. We retrospectively investigated the clinical features and outcomes of patients with IPF and HF.
Methods
We examined the data of patients with IPF who were admitted for HF to the Kindai University Hospital from January 2008 to December 2018.
Results
During the study period, 37 patients with IPF were hospitalized because of HF. Among the 34 patients finally included in the study, 17 (50.0%) were diagnosed with HFpEF, 6 (17.6%) with HFrEF, and 11 (32.3%) with HFPH. Patients with HFrEF had significantly higher values for B-type natriuretic peptide (BNP), and left ventricular (LV) end-systolic and end-diastolic diameters than patients with HFpEF and HFPH (BNP: P = 0.01 and P = 0.0004, LV end-systolic diameter: P < 0.0001 and P < 0.0001, and LV end-diastolic diameter: P = 0.01 and P = 0.0004, respectively). Notably, the difference between the LVEFs of the patients with HFpEF or HFPH was not significant. The patients with HFpEF had the best 30-day mortality rate (0%, P = 0.02).
Conclusions
In patients with IPF, HFpEF is the most common type of HF that requires nonelective hospitalization. Patients with HFpEF survived longer than patients with the 2 other types of HF.
Keywords
heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, idiopathic pulmonary fibrosis, pulmonary hypertension
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Research article
Heart failure as a cause of hospitalization in IPF: comparison of the HFpEF, HFrEF, and PH
Osamu Nishiyama
Kindai University, Faculty of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9163-9605
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 11 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fibrosing lung disease. Some IPF patients require hospitalization because of heart failure (HF), including HF with preserved ejection fraction (HFpEF), HF with reduced ejection fraction (HFrEF), and HF due to pulmonary hypertension (HFPH). However, the association between IPF and HF has not been clarified. We retrospectively investigated the clinical features and outcomes of patients with IPF and HF.
Methods
We examined the data of patients with IPF who were admitted for HF to the Kindai University Hospital from January 2008 to December 2018.
Results
During the study period, 37 patients with IPF were hospitalized because of HF. Among the 34 patients finally included in the study, 17 (50.0%) were diagnosed with HFpEF, 6 (17.6%) with HFrEF, and 11 (32.3%) with HFPH. Patients with HFrEF had significantly higher values for B-type natriuretic peptide (BNP), and left ventricular (LV) end-systolic and end-diastolic diameters than patients with HFpEF and HFPH (BNP: P = 0.01 and P = 0.0004, LV end-systolic diameter: P < 0.0001 and P < 0.0001, and LV end-diastolic diameter: P = 0.01 and P = 0.0004, respectively). Notably, the difference between the LVEFs of the patients with HFpEF or HFPH was not significant. The patients with HFpEF had the best 30-day mortality rate (0%, P = 0.02).
Conclusions
In patients with IPF, HFpEF is the most common type of HF that requires nonelective hospitalization. Patients with HFpEF survived longer than patients with the 2 other types of HF.
Figure 1