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Case report
Xiaobing Yang
Guangdong Provincial Hospital of Traditional Chinese Medicine
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare subset of lung cancer with a poor prognosis. As LCNEC is an uncommon malignancy, the optimal treatment for LCNEC has not been established.
Case presentation
: we report a case of a 66-year-old man diagnosed with unresectable, locally advanced LCNEC who presented a partial radiographic response to immunotherapy combined with chemotherapy. Salvage surgery was performed after 4 cycles of docetaxel and cisplatin (DP) regimen plus sintilimab, which is a highly selective, fully human antiprogrammed death-ligand 1 monoclonal antibody. Moreover, a pathologic analysis of the resected piece revealed the absence of residual viable tumor cells.
Conclusion
this case suggests that patients with locally advanced LCNEC may benefit from neoadjuvant chemo-immunotherapy, it is worthy for further study.
Keywords
Lung large-cell carcinoma, PD-1 inhibitor, Chemotherapy, Complete response
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This is a preprint. It has not completed peer review.
Case report
Xiaobing Yang
Guangdong Provincial Hospital of Traditional Chinese Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare subset of lung cancer with a poor prognosis. As LCNEC is an uncommon malignancy, the optimal treatment for LCNEC has not been established.
Case presentation
: we report a case of a 66-year-old man diagnosed with unresectable, locally advanced LCNEC who presented a partial radiographic response to immunotherapy combined with chemotherapy. Salvage surgery was performed after 4 cycles of docetaxel and cisplatin (DP) regimen plus sintilimab, which is a highly selective, fully human antiprogrammed death-ligand 1 monoclonal antibody. Moreover, a pathologic analysis of the resected piece revealed the absence of residual viable tumor cells.
Conclusion
this case suggests that patients with locally advanced LCNEC may benefit from neoadjuvant chemo-immunotherapy, it is worthy for further study.
Figure 1
Figure 2
Figure 3
Figure 4
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