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Research
Limited Recurrence Distance of Glioblastoma Under Modern Radiotherapy Era
Shiyi Peng
Jiangxi Cancer Hospital
Corresponding Author
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Background: The optimal treatment volume for Glioblastoma multiforme (GBM) is still a subject of debate worldwide. The current study was aimed to determine the distances between recurring tumors and the edge of primary lesions, and thereby provide evidence for accurate target area delineation.
Methods: Between October 2007 and March 2019, 68 recurrent patients with GBM were included in our study. We measured the distance from the initial tumor to the recurrent lesion of GBM patients by expanding the initial gross tumor volume (GTV) to overlap the center of recurrent lesion, with the help of the Pinnacle Treatment Planning System.
Results: Recurrences were local in 56(82.3%) patients, distant in 21(30.9%) patients, and both in 9(13.2%) patients. Factors significantly influencing local recurrence were age (P = 0.049), sex (P = 0.049), and the size of peritumoral edema (P = 0.00). A total number of 91 recurrent tumors were analyzed. All local recurrences occurred within 2cm and 94.8% (55/58) occurred within 1cm of the original GTV based on T1 enhanced imaging. All local recurrences occurred within 1.5 cm and 98.3%(57/58) occurred within 0.5 cm of the original GTV based on T2-FLAIR imaging. 90.9% (30/33) and 81.8% (27/33) distant recurrences occurred ＞3 cm of T1 enhanced and T2-Flair primary tumor margins, respectively.
Conclusions: The 1cm margin from T1 enhanced lesions and 0.5cm margin from T2-Flair abnormal lesions could cover 94.8% and 98.3% local recurrences respectively, which deserves further prospective study as a limited but effective target area.
Keywords
Glioblastoma multiforme (GBM), radiotherapy, recurrent distance, peritumoral edema
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Research
Limited Recurrence Distance of Glioblastoma Under Modern Radiotherapy Era
Shiyi Peng
Jiangxi Cancer Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 10 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The optimal treatment volume for Glioblastoma multiforme (GBM) is still a subject of debate worldwide. The current study was aimed to determine the distances between recurring tumors and the edge of primary lesions, and thereby provide evidence for accurate target area delineation.
Methods: Between October 2007 and March 2019, 68 recurrent patients with GBM were included in our study. We measured the distance from the initial tumor to the recurrent lesion of GBM patients by expanding the initial gross tumor volume (GTV) to overlap the center of recurrent lesion, with the help of the Pinnacle Treatment Planning System.
Results: Recurrences were local in 56(82.3%) patients, distant in 21(30.9%) patients, and both in 9(13.2%) patients. Factors significantly influencing local recurrence were age (P = 0.049), sex (P = 0.049), and the size of peritumoral edema (P = 0.00). A total number of 91 recurrent tumors were analyzed. All local recurrences occurred within 2cm and 94.8% (55/58) occurred within 1cm of the original GTV based on T1 enhanced imaging. All local recurrences occurred within 1.5 cm and 98.3%(57/58) occurred within 0.5 cm of the original GTV based on T2-FLAIR imaging. 90.9% (30/33) and 81.8% (27/33) distant recurrences occurred ＞3 cm of T1 enhanced and T2-Flair primary tumor margins, respectively.
Conclusions: The 1cm margin from T1 enhanced lesions and 0.5cm margin from T2-Flair abnormal lesions could cover 94.8% and 98.3% local recurrences respectively, which deserves further prospective study as a limited but effective target area.
Figure 1
Figure 2
Figure 3
Figure 4