This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Behzad Kazemi Haki
Urmia University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2741-2166
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study was designed to assess the effect of dexmedetomidine on the effect of dexmedetomidine with bupivacaine combination and only bupivacaine on sensory and motor block time, pain score, and hemodynamic variations in supraclavicular block in upper extremity orthopedic surgery.
Methods: This prospective double-blind study was performed on 60 patients aged 20-60 years who were candidates for upper extremity orthopedic surgeries. The sensory block was evaluated using the pinprick method and motor block by the modified Bromage scale method. The post-operative pain was assessed by a visual analog scale.
Results: The mean onset time of sensory and motor block in patients receiving bupivacaine alone was respectively 31.03± 9.65 min and 24.66 ± 9.2 min and in the dexmedetomidine receiving group was about 21.36±8.34 min and 15.93 ± 6.36 minutes. The changes in heart rate and mean arterial blood pressure was similar in both groups. The duration of sensory and motor block and the time of the first analgesia request in the intervention group were longer. Postoperative pain was lower in the intervention group for 24 hours (P = 0.001).
Conclusion: The use of dexmedetomidine plus bupivacaine, without side effects, reduced the onset time of sense and motor blocks and increased the duration of numbness and immobility. Also, dexmedetomidine reduced postoperative pain significantly in use with bupivacaine for supraclavicular blocks.
Trial registration: IRCT, IRCT20160430027677N15. Registered 05/28/2019, http:// https://www.irct.ir/trial/39463
Keywords
Dexmedetomidine, Bupivacaine, Postoperative Pain, Analgesia, Upper extremity, Orthopedic Surgery, Supraclavicular, Block, Humans, Double-Blind Method.
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Behzad Kazemi Haki
Urmia University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2741-2166
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 21 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study was designed to assess the effect of dexmedetomidine on the effect of dexmedetomidine with bupivacaine combination and only bupivacaine on sensory and motor block time, pain score, and hemodynamic variations in supraclavicular block in upper extremity orthopedic surgery.
Methods: This prospective double-blind study was performed on 60 patients aged 20-60 years who were candidates for upper extremity orthopedic surgeries. The sensory block was evaluated using the pinprick method and motor block by the modified Bromage scale method. The post-operative pain was assessed by a visual analog scale.
Results: The mean onset time of sensory and motor block in patients receiving bupivacaine alone was respectively 31.03± 9.65 min and 24.66 ± 9.2 min and in the dexmedetomidine receiving group was about 21.36±8.34 min and 15.93 ± 6.36 minutes. The changes in heart rate and mean arterial blood pressure was similar in both groups. The duration of sensory and motor block and the time of the first analgesia request in the intervention group were longer. Postoperative pain was lower in the intervention group for 24 hours (P = 0.001).
Conclusion: The use of dexmedetomidine plus bupivacaine, without side effects, reduced the onset time of sense and motor blocks and increased the duration of numbness and immobility. Also, dexmedetomidine reduced postoperative pain significantly in use with bupivacaine for supraclavicular blocks.
Trial registration: IRCT, IRCT20160430027677N15. Registered 05/28/2019, http:// https://www.irct.ir/trial/39463
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
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