Lens-induced hypopyon uveitis as the presenting manifestation of posterior lens nucleus dislocation following pars-plana vitrectomy: case report


 A 57-year-old otherwise healthy male presented to our department seven days following uneventful pars-plana vitrectomy with gas tamponade for a superior bullous retinal detachment in the left eye. Ophthalmic examination revealed anterior segment inflammation with hypopyon and fibrinous exudate. Intra-ocular pressure was 28 mm Hg. Posterior segment evaluation was difficult to assess due to the presence of anterior capsule opacification and gas bubble. A Toxic Anterior Segment Syndrome was suspected and the patient was treated with topical and oral steroid medication associated with anti-glaucomatous therapy. On follow-up, anterior segment inflammation and ocular hypertension improved. On day ten post-operatively, ocular ultrasonography demonstrated lens material inferiorly with attached retina. The final diagnosis of posterior lens nucleus dislocation with lens-material antigenic uveitis was retained. The patient underwent an uneventful second vitrectomy with aspiration of the dislocated lens nucleus and sulcus three piece-lens implantation. On last follow-up, visual acuity was 20/50 with no relapsing of ocular inflammation and the retina remained reattached.


Introduction
Posterior nucleus dislocation with intact anterior capsule is a rare, sight-threatening condition. It has been predominantly described in ocular trauma or inadvertent posterior capsular tear during cataract surgery and scarcely in hypermature cataracts. Although lens injuries during pars plana vitrectomy are common, data on posterior nucleus dislocation are scarce. 1,2 We describe an unusual case of posterior lens nucleus dislocation manifesting with lens-material antigenic uveitis following pars-plana vitrectomy with intra-vitreal gas injection for rhegmatogenous retinal detachment.

Case Presentation
A 57-year-old otherwise healthy male presented to our department with sudden mild eye pain. Seven days earlier, he had undergone pars-plana vitrectomy for superior bullous rhegmatogenous retinal detachment caused by a superior horseshoe retinal tear. Surgical procedure consisted of three-port 23-gauge pars plana vitrectomy. The trocars were introduced 4 mm posterior to the limbus managing a scleral tunnel.
Core and peripheral vitrectomy was performed uneventfully. Subretinal uid was drained under per uorocarbon liquid. Cryopexy was applied transsclerally on the retinal tear. Per uorocarbon/air exchange was then performed. One superior trocar was removed and the sclerotomy was sutured with 7.0 absorbable thread followed by air-SF6 20% exchange. The gas was injected continuously from the terminal trocar and the air extrusion was controlled by the other left trocar. After suturing the remaining sclerotomies, the globe was hypotonic on nger pressure. Therefore a complement of injection of SF6 20% was added with 30 gauge syringe 4 mm from the limbus in the superior quadrant.
The following day, ophthalmic examination was unremarkable as the patient had positive light perception with a quiet anterior chamber, and an intra-ocular pressure (IOP) of 23 mm Hg. The lens examination showed a subcapsular posterior cataract. The retina was at posterior to the bubble. The patient was discharged on day one post-operatively and topical corticosteroid and antibiotics were prescribed. Seven days later, he presented with sudden photophobia, mild eye pain and hyperemia. On ophthalmic examination, the visual acuity was limited to positive light perception with mild corneal edema, and the IOP was 30 mm Hg. A slight hypopyon was noted inferiorly with a brinous exudate (Fig. 1). Posterior segment evaluation was hindered by the anterior segment in ammation. Ultrasonography B-scan was ineffective due to the complete gas bubble.

Differential diagnoses included infectious endophthalmitis and Toxic Anterior Segment Syndrome
(TASS). The absence of severe pain, eyelid edema, chemosis and the mild eye redness were against the diagnosis of post-operative endophthalmitis.
The patient was treated with topical mydriatics and topical and oral corticosteroids (prednisolone, 60 mg/day). On day ten post-operatively, the anterior segment in ammation had resolved and good pupillary dilation was obtained revealing centrally clouded anterior capsule with absence of nucleus ( Fig. 1).
Fundus examination was hindered by the lens capsule opaci cation. B-scan ultrasonography revealed a globular echogenic structure in the inferior posterior vitreous cavity resting on the retina corresponding to a dislocated lens nucleus (Fig. 1). The nal diagnosis of posterior nucleus dislocation with lens-material antigenic uveitis was retained.
Reviewing the surgical procedure video, the posterior capsule tear had been detected when completing the gas injection with 30-gauge syringe, the globe being hypotonic and the angle of injection too anteriorly placed.
Medications were continued with a good control of ocular in ammation. Three weeks later, the patient underwent uneventful 25-gauge vitrectomy with aspiration of the soft nucleus. The anterior capsule opaci cation was removed by pars plana approach with the vitrector and a sulcus three piece-lens implantation was performed (Fig. 2).

Discussion
This patient developed lens nucleus dislocation into the vitreous cavity following pars plana vitrectomy with gas tamponade. The lens dislocation remained quiescent during the early follow-up period until a secondary lens-material antigenic uveitis with hypopyon became symptomatic and subsequently was con rmed with B-scan ultrasonography.
Iatrogenic cataract due to posterior capsule injury is a rare, but well-known complication of pars plana vitrectomy and intravitreal injection. 1,3−5 However, there are a very few reported cases of iatrogenic lens nucleus dislocation following vitrectomy. 1 The posterior capsule rupture in our patient probably occurred during completion of the gas injection with 30-gauge syringe due to inappropriate angle of injection in a hypotonic vitrectomized eye leading to posterior lens displacement. The majority of previously described patients with iatrogenic nucleus dislocation during vitrectomy had a history of ocular trauma or multiple eye surgeries to account for their lens zonulas weakness and possible posterior lens displacement, which could increase the risk for iatrogenic posterior capsule rupture. 1 Our patient presented with no history of trauma, exfoliation syndrome, or any other ocular condition associated with zonula weakening.
Unlike our case, none of the previously described patients with iatrogenic nucleus dislocation exhibited features of severe anterior chamber in ammation, such as hypopyon or brinous exudate. A careful clinical and ultrasonography examination was essential in our patient to rule out infectious endophthalmitis and TASS and to establish a de nitive diagnosis of lens-material induced hypopyon uveitis associated with posterior lens nucleus dislocation.
Management in our case consisted of intensive corticosteroid and anti-glaucomatous medications followed, as previously described, by pars plana approach for the soft nucleus aspiration. 1 Consistent with previous data, a three-piece IOL implanted in the sulcus led to good visual outcome in our patient. 1,6 Completing the gas injection at the end of pars plana vitrectomy with gas tamponade is a rather common procedure among vitreoretinal surgeons in order to obtain a complete bubble. However, the syringe should be placed cautiously and the angle should be taken into account in phakic patient to prevent lens injuries.
In any case, a diagnosis of posterior lens nucleus dislocation causing lens-materiel antigenic reaction should be considered in the differential diagnosis of post-vitrectomy uveitis with or without hypopyon. Consent for publication : consent for publication was obtained from the patient Availability of data and material: The datasets used and/or analysed during the current study are available from the corresponding author on request.

Abbreviations
Competing interests: The authors declare that they have no competing interests Funding : no funding was recieved Authors' contributions : IK and IS collected data. NA and IK analyzed and interpreted the patient's data.
MBHT and SA drafted the manuscript. SA and MK provided critical manuscript revisions. All authors read and approved the nal manuscript.