Large-scale slender beam structures with weak stiffness are widely used in the aviation field. There will be a great deformation problem in machining because the overall stiffness of slender beam parts is lower. Firstly, the cutting mechanism and stability theory of the Ti6Al4V material are analyzed, and then the auxiliary support is carried out according to the machining characteristics of the slender beam structure. The feasibility of the deformation suppression measures for the slender beam is verified by experiments. The experimental analysis shows that on the basis of fulcrum auxiliary support, the filling of paraffin melt material is capable of increasing the damping of the whole system, improving the overall stiffness of the machining system, and inhibiting the chatter effect of machining. This method is effective to greatly improve the accuracy and efficiency during machining of slender beam parts. On the premise of the method of processing support with the combination of fulcrum and paraffin, if the tool wear is effectively controlled, the high precision machining of large-scale slender beams can be realized effectively, and the machining deformation of slender beams can be reduced. Although high speed milling has excellent machining effect on the machining accuracy of titanium alloy materials, severe tool wear is observed during high-speed milling of titanium alloy materials. Therefore, high-speed milling of titanium alloy slender beam is suitable to be carried out in the finishing process, which can effectively control tool wear and improve the machining accuracy of parts. Finally, the process verification of typical weak stiffness slender beam skeleton parts is carried out. Through the theoretical and technical support of the experimental scheme, the machining of large-scale slender beam structure parts with weak stiffness is realized.