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Research article
Comparison Of SARS-CoV-2 Virus Variant Genomes Detected In China and USA
Mehmet Cihan Sahingil
TUBITAK Bilgi Guvenligi Ileri Teknolojileri Arastirma Merkezi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4900-2256
License:
This work is licensed under a CC BY 4.0 License. Read Full License
In spreading period of the SARS-CoV-2 virus which is the cause of COVID-19 in the world, it is seen that the genome of the virus mutates and this mutation processes generates new SARS-CoV-2 variants. In this study we investigated the variant genomes which were detected in China and USA. The publicly available SARS-CoV-2 virus genomes, which were detected in human body are multi-aligned and the obtained results reported. There are 87 genomes for China variants and 200 for USA variants in the used data. The analyses are made for each domain of the genomes. The analysis results show that, the variant genomes in the investigated two groups of SARS-CoV-2 have some similar mutation characteristics as well as some characteristic features that differ from each other. The nucleotide mutations in 8782 (C>T mutation) and 28144 (T>C mutation) are common for both of the variant groups. However, in USA variant group some other mutation positions on the variants’ genome were detected. The percentage of missense mutations detected in USA variants is higher than the percentage of synonymous mutations. On the other hand, the percentage of synonymous mutations is higher than the percentage of missense mutations for the variants detected in China. Additionally, the domains where the most mutations are detected on the genome are the regions that affect the interaction of the virus with the host.
Keywords
COVID-19, SARS-CoV-2, Mutation, Genomic Variants, Multi-Alignment
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This is a preprint. It has not completed peer review.
Research article
Comparison Of SARS-CoV-2 Virus Variant Genomes Detected In China and USA
Mehmet Cihan Sahingil
TUBITAK Bilgi Guvenligi Ileri Teknolojileri Arastirma Merkezi
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4900-2256
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 10 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Epigenetics & Genomics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
In spreading period of the SARS-CoV-2 virus which is the cause of COVID-19 in the world, it is seen that the genome of the virus mutates and this mutation processes generates new SARS-CoV-2 variants. In this study we investigated the variant genomes which were detected in China and USA. The publicly available SARS-CoV-2 virus genomes, which were detected in human body are multi-aligned and the obtained results reported. There are 87 genomes for China variants and 200 for USA variants in the used data. The analyses are made for each domain of the genomes. The analysis results show that, the variant genomes in the investigated two groups of SARS-CoV-2 have some similar mutation characteristics as well as some characteristic features that differ from each other. The nucleotide mutations in 8782 (C>T mutation) and 28144 (T>C mutation) are common for both of the variant groups. However, in USA variant group some other mutation positions on the variants’ genome were detected. The percentage of missense mutations detected in USA variants is higher than the percentage of synonymous mutations. On the other hand, the percentage of synonymous mutations is higher than the percentage of missense mutations for the variants detected in China. Additionally, the domains where the most mutations are detected on the genome are the regions that affect the interaction of the virus with the host.
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