See the published version of this article at World Journal of Surgical Oncology.
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Research
Seong Taek Oh
Uijeongbu Saint Mary's Hospital
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at World Journal of Surgical Oncology.
Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer.
Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed.
Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95 % confidence interval [CI] 1.04 – 3.13, p = 0.037, and HR = 1.92, CI 1.02 – 3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS.
Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.
Keywords
sarcopenia, body composition, colorectal neoplasms, self expandable metallic stents
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CURRENT STATUS: Published
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Posted 20 Aug, 2020
Published
On 28 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 16 Aug, 2020
Submission checks complete
On 15 Aug, 2020
Editor invited
On 15 Aug, 2020
No comments provided
Review #1 received
Received 12 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Editor assigned
On 03 Aug, 2020
Reviewers invited
Invitations sent on 03 Aug, 2020
Submission checks complete
On 02 Aug, 2020
Editor invited
On 02 Aug, 2020
No comments provided
Editorial decision: Major Revision
On 16 Jul, 2020
Review #2 received
Received 13 Jul, 2020
Reviewer #2 agreed
On 27 Jun, 2020
Review #1 received
Received 23 Jun, 2020
Reviewer #1 agreed
On 14 Jun, 2020
Reviewers invited
Invitations sent on 09 Jun, 2020
Editor assigned
On 08 Jun, 2020
Submission checks complete
On 07 Jun, 2020
Editor invited
On 07 Jun, 2020
First submitted
On 06 Jun, 2020
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This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Seong Taek Oh
Uijeongbu Saint Mary's Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 20 Aug, 2020
Published
On 28 Aug, 2020
No community comments so far
Editorial decision: Accept
On 17 Aug, 2020
Editor assigned
On 16 Aug, 2020
Submission checks complete
On 15 Aug, 2020
Editor invited
On 15 Aug, 2020
No comments provided
Review #1 received
Received 12 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Editor assigned
On 03 Aug, 2020
Reviewers invited
Invitations sent on 03 Aug, 2020
Submission checks complete
On 02 Aug, 2020
Editor invited
On 02 Aug, 2020
No comments provided
Editorial decision: Major Revision
On 16 Jul, 2020
Review #2 received
Received 13 Jul, 2020
Reviewer #2 agreed
On 27 Jun, 2020
Review #1 received
Received 23 Jun, 2020
Reviewer #1 agreed
On 14 Jun, 2020
Reviewers invited
Invitations sent on 09 Jun, 2020
Editor assigned
On 08 Jun, 2020
Submission checks complete
On 07 Jun, 2020
Editor invited
On 07 Jun, 2020
First submitted
On 06 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at World Journal of Surgical Oncology.
Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer.
Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed.
Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95 % confidence interval [CI] 1.04 – 3.13, p = 0.037, and HR = 1.92, CI 1.02 – 3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS.
Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.
Figure 1
Figure 2
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