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Case Report
Zhenxing Guo
First Hospital of Tsinghua University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8381-7547
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This work is licensed under a CC BY 4.0 License. Read Full License
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and almost universally fatal disease in adults. Due to lack of recognition, under-diagnosis or delayed diagnosis, malignancy related HLH has a poor outcome in adults.
Case Presentation A 60-year-old-female patient was admitted to our hospital with a three day history of weakness and anorexia. Physical examination revealed severe pallor without lymphadenopathy or hepatosplenomegaly. Initial blood test showed hemoglobin level of 26 g/L and platelet count of 76×109/L. Later the patient experienced sustained fever with a maximum temperature of 40°C for one week without any obvious infective symptoms. Biochemical examination revealed high serum ferritin and low natural killer cell viability. The bone marrow morphology showed hemophagocytosis and infiltration with metastatic small cell lung cancer (SCLC). The patient was diagnosed as hemophagocytic lymphohistiocytosis associated with SCLC and underwent chemotherapy. However, the patient progressed rapidly and died within 2 weeks.
Conclusion We reported the first HLH case with SCLC. It is critical to have an early identification of HLH in SCLC patients.
Keywords
hemophagocytic lymphohistiocytosis, fever, bone marrow, small cell lung cancer, case report
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Case Report
Zhenxing Guo
First Hospital of Tsinghua University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8381-7547
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and almost universally fatal disease in adults. Due to lack of recognition, under-diagnosis or delayed diagnosis, malignancy related HLH has a poor outcome in adults.
Case Presentation A 60-year-old-female patient was admitted to our hospital with a three day history of weakness and anorexia. Physical examination revealed severe pallor without lymphadenopathy or hepatosplenomegaly. Initial blood test showed hemoglobin level of 26 g/L and platelet count of 76×109/L. Later the patient experienced sustained fever with a maximum temperature of 40°C for one week without any obvious infective symptoms. Biochemical examination revealed high serum ferritin and low natural killer cell viability. The bone marrow morphology showed hemophagocytosis and infiltration with metastatic small cell lung cancer (SCLC). The patient was diagnosed as hemophagocytic lymphohistiocytosis associated with SCLC and underwent chemotherapy. However, the patient progressed rapidly and died within 2 weeks.
Conclusion We reported the first HLH case with SCLC. It is critical to have an early identification of HLH in SCLC patients.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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