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Research Article
Ying Liu
Peking University Third Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
To compare the differences of brain apparent diffusion coefficient (ADC) values in surviving fetuses, twin controls and single fetus controls using diffusion weighted imaging (DWI) sequence, and to perform follow-up study to reveal the underlying cerebral microstructure changes.
Materials and methods
Thirty-two twins with demise of one fetus, 25 twins, and 20 single fetuses were included. DWI was performed and ADC map was reconstructed automatically. ADC values of certain regions were compared among three-groups, and between left- and right-hemisphere in surviving fetuses. ROC was generated to identify ADC values in surviving fetuses and twin controls.
Results
ADC values were lower in bilateral white matter of frontal lobes (left: 1.68 ± 0.19 vs. 1.91 ± 0.26, 1.88 ± 0.19, P < 0.001; right: 1.68 ± 0.18 vs. 1.86 ± 0.24, 1.84 ± 0.21, P = 0.002), parietal lobes (left: 1.80 ± 0.25 vs. 2.00 ± 0.21, 1.92 ± 0.28, P = 0.012; right: 1.81 ± 0.19 vs. 1.99 ± 0.24, 1.92 ± 0.26, P = 0.012) and occipital lobes (left: 1.72 ± 0.24 vs. 1.87 ± 0.20, 1.70 ± 0.24, P = 0.017; right: 1.73 ± 0.23 vs. 1.91 ± 0.22, 1.70 ± 0.27, P = 0.005) in surviving fetuses compared with twin controls and single fetus, respectively. In discriminating surviving fetuses and twin controls, the area-under-the-curve of ADC values in frontal, parietal and occipital lobes were range from 0.677 to 0.737. The combination of frontal and parietal lobes and gestational age had highest area-under-the-curve (0.771, 95% CI 0.648–0.894).
Conclusions
DWI is a very useful sequence for detecting underlying changes. ADC values might be effective indicators of subtle anomalies in surviving fetuses.
Trial registration:
None.
Keywords
Diffusion weighted imaging, apparent diffusion coefficient, twin pregnancy, demise of one fetus
Figure 1
Figure 2
No competing interests reported.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Ying Liu
Peking University Third Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 06 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
To compare the differences of brain apparent diffusion coefficient (ADC) values in surviving fetuses, twin controls and single fetus controls using diffusion weighted imaging (DWI) sequence, and to perform follow-up study to reveal the underlying cerebral microstructure changes.
Materials and methods
Thirty-two twins with demise of one fetus, 25 twins, and 20 single fetuses were included. DWI was performed and ADC map was reconstructed automatically. ADC values of certain regions were compared among three-groups, and between left- and right-hemisphere in surviving fetuses. ROC was generated to identify ADC values in surviving fetuses and twin controls.
Results
ADC values were lower in bilateral white matter of frontal lobes (left: 1.68 ± 0.19 vs. 1.91 ± 0.26, 1.88 ± 0.19, P < 0.001; right: 1.68 ± 0.18 vs. 1.86 ± 0.24, 1.84 ± 0.21, P = 0.002), parietal lobes (left: 1.80 ± 0.25 vs. 2.00 ± 0.21, 1.92 ± 0.28, P = 0.012; right: 1.81 ± 0.19 vs. 1.99 ± 0.24, 1.92 ± 0.26, P = 0.012) and occipital lobes (left: 1.72 ± 0.24 vs. 1.87 ± 0.20, 1.70 ± 0.24, P = 0.017; right: 1.73 ± 0.23 vs. 1.91 ± 0.22, 1.70 ± 0.27, P = 0.005) in surviving fetuses compared with twin controls and single fetus, respectively. In discriminating surviving fetuses and twin controls, the area-under-the-curve of ADC values in frontal, parietal and occipital lobes were range from 0.677 to 0.737. The combination of frontal and parietal lobes and gestational age had highest area-under-the-curve (0.771, 95% CI 0.648–0.894).
Conclusions
DWI is a very useful sequence for detecting underlying changes. ADC values might be effective indicators of subtle anomalies in surviving fetuses.
Trial registration:
None.
Figure 1
Figure 2
No competing interests reported.
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