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Research article
Mohsen Rokni
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0534-4251
Kazem Ahmadikia
Tehran University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Since December 2019, when SARS-CoV-2 emerged with a cluster of unknown pneumonia cases in Wuhan city and rapidly spread throughout in worldwide and Iran, data have been needed on the clinical and diagnostic features of the affected Iranian patients.
Methods
We extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/praclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between death and non-severe patients.
Results
The mean age of the patients was 49 years, (63%) of the patients were male. The acute respiratory distress syndrome occurred in 64 patients, including 53 who were admitted to the ICU and underwent invasive mechanical ventilation, and 28 who died. On the admission in death group, lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were usually observed. Most patients had a high SII index of > 500 (68%), increased CRP level (88%). A high level of inflammatory index’s such as NLR, PLR and SII in death comparison with moderate groups were observed (P < 0.001). The most common symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). On admission, ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%).
In Conclusion
These patients often presented without fever, and some did not have abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.
Keywords
COVID-19, SARS-CoV-2, Death, Pneumonia, Cytokine storm, Immune response, CT scans, ARDS, Ground-glass opacities
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Editorial decision: Accept
On 22 Oct, 2020
Reviewer #1 agreed
On 02 Oct, 2020
Review #1 received
Received 02 Oct, 2020
Reviewers invited
Invitations sent on 01 Oct, 2020
Editor assigned
On 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
Version 1
Posted 19 Jun, 2020
No comments provided
Review #2 received
Received 06 Aug, 2020
Editorial decision: Major revision
On 06 Aug, 2020
Reviewer #3 agreed
On 21 Jul, 2020
Review #1 received
Received 02 Jul, 2020
Reviewer #2 agreed
On 27 Jun, 2020
Reviewer #1 agreed
On 22 Jun, 2020
Reviewers invited
Invitations sent on 20 Jun, 2020
Editor assigned
On 18 Jun, 2020
Submission checks complete
On 17 Jun, 2020
Editor invited
On 17 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Mohsen Rokni
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0534-4251
Kazem Ahmadikia
Tehran University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Editorial decision: Accept
On 22 Oct, 2020
Reviewer #1 agreed
On 02 Oct, 2020
Review #1 received
Received 02 Oct, 2020
Reviewers invited
Invitations sent on 01 Oct, 2020
Editor assigned
On 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
Version 1
Posted 19 Jun, 2020
No comments provided
Review #2 received
Received 06 Aug, 2020
Editorial decision: Major revision
On 06 Aug, 2020
Reviewer #3 agreed
On 21 Jul, 2020
Review #1 received
Received 02 Jul, 2020
Reviewer #2 agreed
On 27 Jun, 2020
Reviewer #1 agreed
On 22 Jun, 2020
Reviewers invited
Invitations sent on 20 Jun, 2020
Editor assigned
On 18 Jun, 2020
Submission checks complete
On 17 Jun, 2020
Editor invited
On 17 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background
Since December 2019, when SARS-CoV-2 emerged with a cluster of unknown pneumonia cases in Wuhan city and rapidly spread throughout in worldwide and Iran, data have been needed on the clinical and diagnostic features of the affected Iranian patients.
Methods
We extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/praclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between death and non-severe patients.
Results
The mean age of the patients was 49 years, (63%) of the patients were male. The acute respiratory distress syndrome occurred in 64 patients, including 53 who were admitted to the ICU and underwent invasive mechanical ventilation, and 28 who died. On the admission in death group, lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were usually observed. Most patients had a high SII index of > 500 (68%), increased CRP level (88%). A high level of inflammatory index’s such as NLR, PLR and SII in death comparison with moderate groups were observed (P < 0.001). The most common symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). On admission, ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%).
In Conclusion
These patients often presented without fever, and some did not have abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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