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Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy to diagnose small gastric subepithelial lesions:A propencity score matching analysis
Eikichi Ihara
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7070-6610
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Gastroenterology.
Background Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the gold standard for diagnosing gastric subepithelial lesions, alternative open biopsy procedures, such as mucosal incision-assisted biopsy (MIAB) has been reported useful. The aim of this study is to evaluate the efficacy of MIAB for the diagnosis of gastric SELs compared with EUS-FNAB.
Methods We retrospectively analyzed medical records of 177 consecutive patients with gastric SELs who underwent either MIAB or EUS-FNAB at five hospitals in Japan between January 2010 and January 2018. Diagnostic yield, procedural time, and adverse event rates for the two procedures were evaluated before and after propensity-score matching.
Results No major procedure-related adverse events were observed in either group. Both procedures yielded highly-accurate diagnoses once large enough samples were obtained; however, such successful sampling was more often accomplished by MIAB than by EUS-FNAB, especially for small SELs. As a result, MIAB provided better diagnostic yields for SELs smaller than 20-mm diameter. The diagnostic yields of both procedures were comparable for SELs larger than 20-mm diameter; however, MIAB required significantly longer procedural time (approximately 13 minutes) compared with EUS-FNAB.
Conclusions Although MIAB required longer procedural time, it outperformed EUS-FNAB when diagnosing gastric SELs smaller than 20-mm diameter.
Keywords
subepithelial lesion, mucosal incision-assisted biopsy, ultrasound-guided fine needle aspiration biopsy
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CURRENT STATUS: Published
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Posted 10 Jan, 2020
Published
On 21 Jan, 2020
No community comments so far
Submission checks complete
On 08 Jan, 2020
Editorial decision: Accept
On 08 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 06 Jan, 2020
Review #2 received
Received 19 Dec, 2019
Reviewers invited
Invitations sent on 19 Dec, 2019
Reviewer #1 agreed
On 19 Dec, 2019
Reviewer #2 agreed
On 19 Dec, 2019
Review #1 received
Received 19 Dec, 2019
Editor assigned
On 17 Dec, 2019
Submission checks complete
On 16 Dec, 2019
Editor invited
On 16 Dec, 2019
No comments provided
Editorial decision: Major revision
On 17 Sep, 2019
Review #2 received
Received 08 Sep, 2019
Reviewer #2 agreed
On 05 Sep, 2019
Review #1 received
Received 21 Aug, 2019
Reviewer #1 agreed
On 10 Aug, 2019
Editor assigned
On 09 Aug, 2019
Reviewers invited
Invitations sent on 09 Aug, 2019
Submission checks complete
On 06 Aug, 2019
Editor invited
On 06 Aug, 2019
First submitted
On 22 Jul, 2019
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Subject Areas
Gastroenterology & Hepatology
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This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy to diagnose small gastric subepithelial lesions:A propencity score matching analysis
Eikichi Ihara
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7070-6610
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 10 Jan, 2020
Published
On 21 Jan, 2020
No community comments so far
Submission checks complete
On 08 Jan, 2020
Editorial decision: Accept
On 08 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 06 Jan, 2020
Review #2 received
Received 19 Dec, 2019
Reviewers invited
Invitations sent on 19 Dec, 2019
Reviewer #1 agreed
On 19 Dec, 2019
Reviewer #2 agreed
On 19 Dec, 2019
Review #1 received
Received 19 Dec, 2019
Editor assigned
On 17 Dec, 2019
Submission checks complete
On 16 Dec, 2019
Editor invited
On 16 Dec, 2019
No comments provided
Editorial decision: Major revision
On 17 Sep, 2019
Review #2 received
Received 08 Sep, 2019
Reviewer #2 agreed
On 05 Sep, 2019
Review #1 received
Received 21 Aug, 2019
Reviewer #1 agreed
On 10 Aug, 2019
Editor assigned
On 09 Aug, 2019
Reviewers invited
Invitations sent on 09 Aug, 2019
Submission checks complete
On 06 Aug, 2019
Editor invited
On 06 Aug, 2019
First submitted
On 22 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Gastroenterology.
Background Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the gold standard for diagnosing gastric subepithelial lesions, alternative open biopsy procedures, such as mucosal incision-assisted biopsy (MIAB) has been reported useful. The aim of this study is to evaluate the efficacy of MIAB for the diagnosis of gastric SELs compared with EUS-FNAB.
Methods We retrospectively analyzed medical records of 177 consecutive patients with gastric SELs who underwent either MIAB or EUS-FNAB at five hospitals in Japan between January 2010 and January 2018. Diagnostic yield, procedural time, and adverse event rates for the two procedures were evaluated before and after propensity-score matching.
Results No major procedure-related adverse events were observed in either group. Both procedures yielded highly-accurate diagnoses once large enough samples were obtained; however, such successful sampling was more often accomplished by MIAB than by EUS-FNAB, especially for small SELs. As a result, MIAB provided better diagnostic yields for SELs smaller than 20-mm diameter. The diagnostic yields of both procedures were comparable for SELs larger than 20-mm diameter; however, MIAB required significantly longer procedural time (approximately 13 minutes) compared with EUS-FNAB.
Conclusions Although MIAB required longer procedural time, it outperformed EUS-FNAB when diagnosing gastric SELs smaller than 20-mm diameter.
Figure 1
Figure 2
Due to technical limitations the tables are available as a download in the Supplementary Files.