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Research Article
Naya Talal Hassan
Tishreen University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-3833-8130
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Non-Hodgkin lymphoma is the fourth most common malignancy in children and it is not considered to be a hereditary disorder. However, it could affect members from the same family.
Case presentation: We are presenting two cases of Caucasian female siblings who were diagnosed with mediastinal lymphoblastic lymphoma in the same year. The two young females were presented to the emergency department with respiratory symptoms. After doing radiological investigations and biopsies, the diagnosis of lymphoblastic lymphoma was done. The elder sister died before confirming the diagnosis, and the other one is on chemotherapy now and the treatment outcomes is good.
Conclusions: This case emphasize the crucial role of precursor genetics in lymphoblastic lymphomas and suggesting the strong relation between those genetics and the age of symptoms presentation. This is the first report of non-Hodgkin siblings pair in the pediatric population.
Keywords
Lymphoblastic Lymphoma, Non-Hodgkin Lymphoma, Familial Cancer, Mediastinal Mass, Case Report.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Naya Talal Hassan
Tishreen University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-3833-8130
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Journal of Medical Case Reports.
Version 1
Posted 03 May, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cancer Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Medical Case Reports.
Background: Non-Hodgkin lymphoma is the fourth most common malignancy in children and it is not considered to be a hereditary disorder. However, it could affect members from the same family.
Case presentation: We are presenting two cases of Caucasian female siblings who were diagnosed with mediastinal lymphoblastic lymphoma in the same year. The two young females were presented to the emergency department with respiratory symptoms. After doing radiological investigations and biopsies, the diagnosis of lymphoblastic lymphoma was done. The elder sister died before confirming the diagnosis, and the other one is on chemotherapy now and the treatment outcomes is good.
Conclusions: This case emphasize the crucial role of precursor genetics in lymphoblastic lymphomas and suggesting the strong relation between those genetics and the age of symptoms presentation. This is the first report of non-Hodgkin siblings pair in the pediatric population.
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
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