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Ohk-Hyun Ryu
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1118-6886
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of cardiovascular disease. However, the relationshipbetween metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the associationbetween metabolic syndrome and dementia,according to the dementia type.
Methods
We analyzed data of 84,144 individuals,in the aged group of more than 60 years,between January 1, 2009,to December 31, 2009, at Gangwon province by using the information of the(Korean) National Health Insurance Service. After eight years of gap, in 2017, we investigated the relationship between metabolic syndrome and dementia. We classified Dementia either as dementia of the Alzheimer type (AD) or vascular dementia (VD). AD and VD were defined according to criteria in the International Classification of Disease, Tenth Revision, Clinical Modification codes.
Results
Metabolic syndrome was associated with AD, while it was not associated with VD. All five components of metabolic syndrome were associated with AD, independently. However, among components of metabolic syndrome, only the high glucose level was associated with VD. Body Mass Index (BMI), fasting glucose and smoking were also associated with AD. A history of the previous stroke was associated with both AD and VD.
Conclusions
Metabolic syndrome was associated with AD, while was not associated with VD. VD was associated only with several risk factors that could affect the vascular state rather than a metabolic syndrome. We suggested that the effect of metabolic syndrome on dementia would be different depending on the type of dementia.
Keywords
Metabolic syndrome, National Health Insurance Service, Dementia risk, Alzheimer’s disease, Vascular dementia
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CURRENT STATUS: Published
View the published article at Diabetology & Metabolic Syndrome.
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Editor assigned
On 20 Dec, 2020
Editorial decision: Accept
On 20 Dec, 2020
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On 20 Dec, 2020
Editor invited
On 20 Dec, 2020
Version (no preprint)
Posted 13 Dec, 2020
Reviewer #1 agreed
On 13 Dec, 2020
Review #1 received
Received 13 Dec, 2020
Editorial decision: Minor revision
On 13 Dec, 2020
Editor assigned
On 11 Dec, 2020
Reviewers invited
Invitations sent on 11 Dec, 2020
Submission checks complete
On 11 Dec, 2020
Editor invited
On 11 Dec, 2020
This version was not preprinted
No comments provided
Review #1 received
Received 26 Nov, 2020
Editorial decision: Major revision
On 26 Nov, 2020
Reviewer #2 agreed
On 25 Nov, 2020
Editor assigned
On 25 Nov, 2020
Reviewers invited
Invitations sent on 25 Nov, 2020
Reviewer #1 agreed
On 25 Nov, 2020
Review #2 received
Received 25 Nov, 2020
Submission checks complete
On 25 Nov, 2020
Editor invited
On 25 Nov, 2020
Version 1
Posted 17 Jun, 2020
No comments provided
Editorial decision: Major revision
On 20 Sep, 2020
Reviewer #2 agreed
On 19 Sep, 2020
Review #2 received
Received 19 Sep, 2020
Review #1 received
Received 31 Aug, 2020
Reviewer #1 agreed
On 20 Aug, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Editor assigned
On 15 Jun, 2020
Submission checks complete
On 14 Jun, 2020
Editor invited
On 14 Jun, 2020
First submitted
On 12 Jun, 2020
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PDF Downloads: ...
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Subject Areas
Neurology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Diabetology & Metabolic Syndrome.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Ohk-Hyun Ryu
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1118-6886
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Diabetology & Metabolic Syndrome.
No community comments so far
Editor assigned
On 20 Dec, 2020
Editorial decision: Accept
On 20 Dec, 2020
Submission checks complete
On 20 Dec, 2020
Editor invited
On 20 Dec, 2020
Version (no preprint)
Posted 13 Dec, 2020
Reviewer #1 agreed
On 13 Dec, 2020
Review #1 received
Received 13 Dec, 2020
Editorial decision: Minor revision
On 13 Dec, 2020
Editor assigned
On 11 Dec, 2020
Reviewers invited
Invitations sent on 11 Dec, 2020
Submission checks complete
On 11 Dec, 2020
Editor invited
On 11 Dec, 2020
This version was not preprinted
No comments provided
Review #1 received
Received 26 Nov, 2020
Editorial decision: Major revision
On 26 Nov, 2020
Reviewer #2 agreed
On 25 Nov, 2020
Editor assigned
On 25 Nov, 2020
Reviewers invited
Invitations sent on 25 Nov, 2020
Reviewer #1 agreed
On 25 Nov, 2020
Review #2 received
Received 25 Nov, 2020
Submission checks complete
On 25 Nov, 2020
Editor invited
On 25 Nov, 2020
Version 1
Posted 17 Jun, 2020
No comments provided
Editorial decision: Major revision
On 20 Sep, 2020
Reviewer #2 agreed
On 19 Sep, 2020
Review #2 received
Received 19 Sep, 2020
Review #1 received
Received 31 Aug, 2020
Reviewer #1 agreed
On 20 Aug, 2020
Reviewers invited
Invitations sent on 16 Jun, 2020
Editor assigned
On 15 Jun, 2020
Submission checks complete
On 14 Jun, 2020
Editor invited
On 14 Jun, 2020
First submitted
On 12 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Diabetology & Metabolic Syndrome.
Background
Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of cardiovascular disease. However, the relationshipbetween metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the associationbetween metabolic syndrome and dementia,according to the dementia type.
Methods
We analyzed data of 84,144 individuals,in the aged group of more than 60 years,between January 1, 2009,to December 31, 2009, at Gangwon province by using the information of the(Korean) National Health Insurance Service. After eight years of gap, in 2017, we investigated the relationship between metabolic syndrome and dementia. We classified Dementia either as dementia of the Alzheimer type (AD) or vascular dementia (VD). AD and VD were defined according to criteria in the International Classification of Disease, Tenth Revision, Clinical Modification codes.
Results
Metabolic syndrome was associated with AD, while it was not associated with VD. All five components of metabolic syndrome were associated with AD, independently. However, among components of metabolic syndrome, only the high glucose level was associated with VD. Body Mass Index (BMI), fasting glucose and smoking were also associated with AD. A history of the previous stroke was associated with both AD and VD.
Conclusions
Metabolic syndrome was associated with AD, while was not associated with VD. VD was associated only with several risk factors that could affect the vascular state rather than a metabolic syndrome. We suggested that the effect of metabolic syndrome on dementia would be different depending on the type of dementia.
Figure 1
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