DOI: https://doi.org/10.21203/rs.2.357/v1
Introduction: Hypocalcemia is a derangement in serum calcium level due to a vast spectrum of disorders, but the most common cause is surgery, usually thyroid gland surgery. Symptoms of Hypocalcemia can be due to increased neuromuscular excitation resulting in tetany, paresthesia or seizure. It can also be because of deposition of calcium in soft tissues producing reduced vision /cataract or calcification of basal ganglia. Cataract is the most common ocular symptom of hypocalcemia. Case report: A twenty six years old Ethiopian female patient presented with painless reduction of vision of both eyes 5 years after she was diagnosed to have hypocalcemia with very low serum calcium level (3mg/dl) due to damage to the parathyroid gland during total thyroidectomy for toxic goiter and has been on supplemental calcium gluconate twice daily. She had typical bilateral symmetrical posterior sub capsular cataract with punctate iridescent opacities in the anterior and posterior cortex of the lens. Systemic examination revealed horizontal surgical scar on the anterior neck and Positive Chvostek sign. Conclusion:The work up of bilateral symmetrical cataract in young patients should include serum electrolyte levels, particularly calcium, in those who had history of thyroid surgery. Key words: Hypocalcemia, bilateral cataract, total thyroidectomy, hypoparathyroidism, tetany, serum calcium and Ethiopia.
Thyrotoxicosis is a hyperthyroidism state where various symptoms occur due to a raised level of circulating thyroid hormones. There are four clinical types of the disease namely: diffuse toxic goiter (Graves’ disease), toxic nodular goiter, toxic nodule, hyperthyroidism due to rarer causes.1
Diffuse toxic goiter and toxic nodular goiter with overactive inter-nodular tissue are treated with total thyroidectomy which cures by reducing the mass of overactive tissue.1 Total thyroidectomy is associated with complications such as: hemorrhage, airway obstruction and recurrent laryngeal nerve injury with voice change. Other complications include: thyroid insufficiency, recurrence of thyrotoxicosis and secondary hypoparathyroidism which is transient (can present within 2-5 postoperative days).1 Hypoparathyroidism occurs due to removal of the parathyroid glands or infarction through damage to the parathyroid end artery.1 Permanent hypoparathyroidism is not as such common occurring in less than 1% of cases.1 It is associated with several systemic manifestations of hypocalcemia like tetany, confusion, muscle weakness and paresthesia. Hypocalcemic cataract is one of the long term consequences of hypocalcemia along with papilloedema, basal ganglia calcification, nephrocalcinosis and prolonged QT interval.1, 2 We report a twenty six years old Ethiopian female patient with bilateral cataract with a history of previous thyroid surgery and systemic hypocalcemic symptoms and signs.
A 26 years old female patient came to Jimma University department of ophthalmology (JUDO) with a compliant of bilateral painless and progressive reduction of vision of 2 years duration. She underwent total thyroidectomy seven years back for toxic diffuse goiter. A week after the surgery, she started to have circumoral numbness, paresthesia of the hands and legs, muscle cramp, stiffness of joints, mental confusion and irritability. Then she was diagnosed to have hypocalcemia due to damage to the parathyroid gland during the surgery and has been on supplemental calcium gluconate.
At the time of diagnosis her serum calcium level was very low (3mg/dl) and she was started on calcium gluconate supplement 500mg three times a day. Currently her serum calcium level raised to 8.4 mg/dl (8.2 -10.4 mg/dl) after which she stopped using the supplement and was told to increase calcium reach foods only. She denied any history of trauma to the eye. Otherwise she has no other known systemic diseases like DM, HTN or TB.
On Physical examination her visual acuity (VA) was 6/36 in both eyes. Intra Ocular Pressure(IOP) was 14mmHg in the right and 12mmHg in the left eye. Conjunctiva was quite, cornea was clear and transparent, anterior chamber (AC) depth was +3 with Van Herrick (VH) classification and devoid of cells or flare. Pupil was round regular and reactive, there was no posterior psynechiae in both eyes. There was bilateraly symmetrical posterior sub capsular opacity and punctate iridescent opacities in the anterior and posterior cortex of the lens. (Fig:1). The fundus examination revealed no abnormality. On systemic examination she had horizontal surgical scar on anterior neck and she had Positive Chvostek sign.
Other systemic Investigations revealed no remarkable finding (CBC was with in normal range; ESR was 30mm/hr; FBS was 103mg/dl; VDRL and PIHCT were negative).
With the above findings she was diagnosed to have hypocalcemic cataract and we planned and counseled her to do phacoemulsification with PC-IOL. However the patient wanted to take some time to try alternative (religious) treatment.
Calcium regulation is critical for Normal cell function, Membrane stability, neural transmission, bone structure and blood coagulation. The normal total calcium concentration in the plasma is 8.9 - 10.1 mg/dL (4.5-5.1 mEq/L).2 Hypocalcemia is an electrolyte derangement commonly encountered on surgical and medical services.1, 2 It may be transient, reversing with addressing the underlying cause, or chronic and even lifelong, when due to a genetic disorder or the result of irreversible damage to the parathyroid glands after surgery or secondary to autoimmune destruction.1-3 After thyroidectomy, transient hypoparathyroidism occurs in 5-10% of patients; incidence of transient hypocalcaemia ranges 19-38% and permanent hypocalcemia occurs in 1% of patients.1
Clinical Symptoms of Hypocalcemia can be due to increased neuromuscular excitation resulting in tetany, paresthesia or seizure.1 It can also be because of deposition of calcium in soft tissues producing reduced vision due to cataract, papillaedema or calcification of basal ganglia.4-8 It has been reported that longstanding hypocalcaemia has been remarkably asymptomatic or minimal symptoms like paresthesia.4 Symptomatic long-term hypocalcemia can occur after thyroid surgery with tetany, paresthesia, seizure and confusion.1, 2, 4 The patient presented here had most of the above systemic manifestations which improved with supplemental calcium gluconate.
Hypocalcaemic cataracts are bilateral, punctate, iridescent opacities in the anterior and posterior cortex lying beneath the lens capsule which are usually separated from the lens capsule by a zone of clear lens. The opacities may remain stable or mature into complete cortical cataracts.3 The morphology and bilaterality of the cataract with-out other concomitant primary ocular conditions in the case described here suggests the cause of the cataract to be long-term depreciation of serum calcium level in her body. As far as the authors’ knowledge; there are few reported cases of bilateral cataract secondary to hypocalcemia.5, 6, 8 Freedman and et al reported bilateral cataract secondary to hypocalcaemia presenting 4 years after total thyroidectomy.5 Our patient developed long-term hypocalcemia after total thyroidectomy which took longer time to return back to normal. Her serum calcium level at the time of diagnosis was very low. It took 7 years of treatment to raise her serum calcium level. Chronic hypocalcemia due to hypoparathyroidism is treated with calcium supplements (1000–1500 mg/d elemental calcium in divided doses) and either vitamin D2 or D3 (25,000–100,000 U daily) or calcitriol (1,25(OH)2D, 0.25–2 g/d).2 The patient described here has been on calcium gluconate 500mg tid which is according to the recommended dose; was not taking vitamin D and calcitriol because they were not available in our setup and they are expensive to buy from abroad.
After thyroid surgery, permanent hypocalcemia should be considered as one of the long-term complications and patients should be followed for the symptoms of tetany and serum calcium levels. The work up of bilateral symmetrical cataract in young patients should include serum electrolyte levels, particularly calcium, in those who had history of thyroid surgery.
AC: Anterior Chamber
CBC: Complete Blood Count
DM: Diabetes Mellitus
ESR: Erythrocyte Sedimentation Rate
FBS: Fasting Blood Sugar
HIV: Human Immuno- deficiency Virus
HTN: Hypertension
IOP: Intra ocular pressure
JUDO: Jimma University Department of Ophthalmology
PC-IOL: Posterior Chamber Intra Ocular Lens
PIHCT: Provider Initiative HIV Counseling and Testing
TB: Tuberculosis
VA: Visual Acuity
VDRL: Venereal Disease Research Laboratory
VH: Van Herick
Ethics approval and consent to participate
Patient information was kept confidential with the study investigators only. According to the declaration of Helsinki Ethical Principles for Medical Research, the patients management was irrespective of the consent she has given. Written consent was obtained from the patient.
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Written consent was obtained from the patient.
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Competing interests
Financial interest – there is no financial support to disclose.
None of the authors have any proprietary interests or conflicts of interest related to this submission.
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Authors’ contributions
KTD contributed to the literature search, patient management and manuscript preparation for submission. DK contributed to the literature search, patient management and manuscript