See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Danhong Fang
Wenzhou Medical University First Affiliated Hospital
Corresponding Author
License:
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Background
A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults.
Methods
From May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou Medical University. Univariate and multivariate logistic regression analyses were applied to evaluate a possible relationship between TG/HDL-C ratio and sarcopenia occurrence.
Results
We included 2613 adults in this study, with 13.85% presenting with sarcopenia. The odds ratios (ORs) for TG and HDL-C were 0.67 (95% confidence interval [CI]: 0.51-0.87), and 1.97 (95% CI: 1.49-2.61), respectively. Moreover, TG/HDL-C ratio was independently associated with sarcopenia status (OR: 0.63; 95% CI: 0.49-0.81).
Conclusions
We found that TG and HDL-C were, respectively, negatively and positively associated with sarcopenia occurrence rate in community-dwelling Chinese adults. However, a negative association was found between sarcopenia occurrence rate and TG/HDL-C ratio.
Keywords
sarcopenia, triglyceride, high-density lipoprotein cholesterol, community-dwelling Chinese adults
Figure 1
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- supplementaryFigure.jpg
Supplementary Figure. Receiver operating characteristic (ROC) curve analyses of serum TG, HDL-C and TG/HDL-C ratio in sarcopenia status.
- supplementaryFigure.jpg
Supplementary Figure. Receiver operating characteristic (ROC) curve analyses of serum TG, HDL-C and TG/HDL-C ratio in sarcopenia status.
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CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 6
Posted 17 Nov, 2020
No community comments so far
Editorial decision: Accept
On 19 Nov, 2020
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Editorial decision: Moderate Revision
On 29 Oct, 2020
Editor assigned
On 09 Oct, 2020
Submission checks complete
On 08 Oct, 2020
Editor invited
On 08 Oct, 2020
No comments provided
Editorial decision: Moderate Revision
On 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Submission checks complete
On 27 Sep, 2020
Editor invited
On 27 Sep, 2020
No comments provided
Editorial decision: Moderate Revision
On 18 Sep, 2020
Reviewer #2 agreed
On 13 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Review #1 received
Received 11 Sep, 2020
Reviewers invited
Invitations sent on 10 Sep, 2020
Reviewer #1 agreed
On 10 Sep, 2020
Editor assigned
On 06 Sep, 2020
Submission checks complete
On 05 Sep, 2020
Editor invited
On 05 Sep, 2020
No comments provided
Editorial decision: Major revision
On 27 Aug, 2020
Review #3 received
Received 24 Aug, 2020
Reviewer #4 agreed
On 21 Aug, 2020
Review #4 received
Received 21 Aug, 2020
Reviewer #3 agreed
On 20 Aug, 2020
Reviewer #1 agreed
On 17 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Review #2 received
Received 17 Aug, 2020
Review #1 received
Received 17 Aug, 2020
Editor assigned
On 17 Aug, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
No comments provided
Editorial decision: Major revision
On 22 Jul, 2020
Review #3 received
Received 13 Jul, 2020
Review #4 received
Received 13 Jul, 2020
Reviewer #4 agreed
On 06 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Reviewer #3 agreed
On 05 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 25 Jun, 2020
Review #1 received
Received 25 Jun, 2020
Reviewers invited
Invitations sent on 24 Jun, 2020
First submitted
On 18 Jun, 2020
Editor assigned
On 18 Jun, 2020
Submission checks complete
On 17 Jun, 2020
Editor invited
On 17 Jun, 2020
Metrics
Comments: 0
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HTML Views: ...
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See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Danhong Fang
Wenzhou Medical University First Affiliated Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 6
Posted 17 Nov, 2020
No community comments so far
Editorial decision: Accept
On 19 Nov, 2020
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Editorial decision: Moderate Revision
On 29 Oct, 2020
Editor assigned
On 09 Oct, 2020
Submission checks complete
On 08 Oct, 2020
Editor invited
On 08 Oct, 2020
No comments provided
Editorial decision: Moderate Revision
On 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Submission checks complete
On 27 Sep, 2020
Editor invited
On 27 Sep, 2020
No comments provided
Editorial decision: Moderate Revision
On 18 Sep, 2020
Reviewer #2 agreed
On 13 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Review #1 received
Received 11 Sep, 2020
Reviewers invited
Invitations sent on 10 Sep, 2020
Reviewer #1 agreed
On 10 Sep, 2020
Editor assigned
On 06 Sep, 2020
Submission checks complete
On 05 Sep, 2020
Editor invited
On 05 Sep, 2020
No comments provided
Editorial decision: Major revision
On 27 Aug, 2020
Review #3 received
Received 24 Aug, 2020
Reviewer #4 agreed
On 21 Aug, 2020
Review #4 received
Received 21 Aug, 2020
Reviewer #3 agreed
On 20 Aug, 2020
Reviewer #1 agreed
On 17 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Review #2 received
Received 17 Aug, 2020
Review #1 received
Received 17 Aug, 2020
Editor assigned
On 17 Aug, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
No comments provided
Editorial decision: Major revision
On 22 Jul, 2020
Review #3 received
Received 13 Jul, 2020
Review #4 received
Received 13 Jul, 2020
Reviewer #4 agreed
On 06 Jul, 2020
Review #2 received
Received 06 Jul, 2020
Reviewer #3 agreed
On 05 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 25 Jun, 2020
Review #1 received
Received 25 Jun, 2020
Reviewers invited
Invitations sent on 24 Jun, 2020
First submitted
On 18 Jun, 2020
Editor assigned
On 18 Jun, 2020
Submission checks complete
On 17 Jun, 2020
Editor invited
On 17 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Lipids in Health and Disease.
Background
A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults.
Methods
From May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou Medical University. Univariate and multivariate logistic regression analyses were applied to evaluate a possible relationship between TG/HDL-C ratio and sarcopenia occurrence.
Results
We included 2613 adults in this study, with 13.85% presenting with sarcopenia. The odds ratios (ORs) for TG and HDL-C were 0.67 (95% confidence interval [CI]: 0.51-0.87), and 1.97 (95% CI: 1.49-2.61), respectively. Moreover, TG/HDL-C ratio was independently associated with sarcopenia status (OR: 0.63; 95% CI: 0.49-0.81).
Conclusions
We found that TG and HDL-C were, respectively, negatively and positively associated with sarcopenia occurrence rate in community-dwelling Chinese adults. However, a negative association was found between sarcopenia occurrence rate and TG/HDL-C ratio.
Figure 1
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- supplementaryFigure.jpg
Supplementary Figure. Receiver operating characteristic (ROC) curve analyses of serum TG, HDL-C and TG/HDL-C ratio in sarcopenia status.
- supplementaryFigure.jpg
Supplementary Figure. Receiver operating characteristic (ROC) curve analyses of serum TG, HDL-C and TG/HDL-C ratio in sarcopenia status.
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