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Research
Na Yang
Zhejiang University School of Medicine Sir Run Run Shaw Hospital
Corresponding Author
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Background: In this study, we aimed to investigate the dynamic changes of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain whether these changes were associated with the prognosis of the disease.
Methods: This retrospective study was conducted at a tertiary critical care center in China. We included sHTGP patients who were admitted within 72h after AP onset. All the sHTGP patients received DFPP within 24h after admission. Lipid profile changes was measured in 47 patients with sHTGP on admission, consecutive 4 days after DFPP and at discharge. According to the TG levels in the first day after DFPP, we divided patients into two group: non-target (TG>5.6mmol/L) and target group (TG ≤5.6mmol/L). Propensity score matching was used to investigate association between TG-lowering effect and the prognosis. Linear regression analysis on four models was used to determine the relationship between other lipid parameters and the outcome.
Results: Except for low density lipoprotein, all the parameters of lipid profile at disease onset showed significant difference from their normal levels. The median serum triglyceride (TG) level of the sHTGP patients was 42.9 mmol/L on admission. In the first day after DFPP, serum TG, cholesterol (TC) and very low density lipoprotein decreased significantly, and the high-density lipoprotein (HDL) as well as apoprotein A1 increased meanwhile. TG continued to fall for the following three days and the other indicators held steady. After propensity score matching, the hospitalization duration was significantly lower in the target group (14.5 [13.0, 16.0] vs 8.0 [6.0, 15.3], P=0.035). Linear regression analysis revealed that the levels of HDL were negatively associated with the duration of hospitalization in three adjusted models.
Conclusion: There was distinct fluctuation of the lipid profile upon the burst of sHTGP and the parameters changed significantly in the first day after DFPP. Among these parameters, HDL may serve as a biomarker for disease prognosis in patients with sHTGP. Moreover, reaching the TG-lowering target of 5.6mmol/L may shorten hospitalization duration.
Keywords
Severe hypertriglyceridemia-induced acute pancreatitis, Double filtration plasma apheresis, Lipid profile, High-density lipoprotein
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CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
No community comments so far
Editorial decision: Accept
On 31 Aug, 2020
Review #5 received
Received 29 Aug, 2020
Reviewer #5 agreed
On 25 Aug, 2020
Review #4 received
Received 17 Aug, 2020
Reviewer #4 agreed
On 17 Aug, 2020
Review #2 received
Received 17 Aug, 2020
Review #3 received
Received 17 Aug, 2020
Editor assigned
On 17 Aug, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Reviewer #1 agreed
On 17 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #3 agreed
On 17 Aug, 2020
Review #1 received
Received 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
Version 1
Posted 18 Jun, 2020
No comments provided
Review #6 received
Received 02 Jul, 2020
Editorial decision: Major revision
On 02 Jul, 2020
Reviewer #6 agreed
On 27 Jun, 2020
Review #4 received
Received 24 Jun, 2020
Reviewer #5 agreed
On 21 Jun, 2020
Review #5 received
Received 21 Jun, 2020
Review #2 received
Received 19 Jun, 2020
Review #3 received
Received 19 Jun, 2020
Review #1 received
Received 19 Jun, 2020
Reviewer #4 agreed
On 18 Jun, 2020
Editor assigned
On 17 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Reviewer #1 agreed
On 17 Jun, 2020
Reviewer #2 agreed
On 17 Jun, 2020
Reviewer #3 agreed
On 17 Jun, 2020
First submitted
On 16 Jun, 2020
Submission checks complete
On 16 Jun, 2020
Editor invited
On 16 Jun, 2020
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A new preprint design is coming!
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See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Na Yang
Zhejiang University School of Medicine Sir Run Run Shaw Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
No community comments so far
Editorial decision: Accept
On 31 Aug, 2020
Review #5 received
Received 29 Aug, 2020
Reviewer #5 agreed
On 25 Aug, 2020
Review #4 received
Received 17 Aug, 2020
Reviewer #4 agreed
On 17 Aug, 2020
Review #2 received
Received 17 Aug, 2020
Review #3 received
Received 17 Aug, 2020
Editor assigned
On 17 Aug, 2020
Reviewers invited
Invitations sent on 17 Aug, 2020
Reviewer #1 agreed
On 17 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #3 agreed
On 17 Aug, 2020
Review #1 received
Received 17 Aug, 2020
Submission checks complete
On 16 Aug, 2020
Editor invited
On 16 Aug, 2020
Version 1
Posted 18 Jun, 2020
No comments provided
Review #6 received
Received 02 Jul, 2020
Editorial decision: Major revision
On 02 Jul, 2020
Reviewer #6 agreed
On 27 Jun, 2020
Review #4 received
Received 24 Jun, 2020
Reviewer #5 agreed
On 21 Jun, 2020
Review #5 received
Received 21 Jun, 2020
Review #2 received
Received 19 Jun, 2020
Review #3 received
Received 19 Jun, 2020
Review #1 received
Received 19 Jun, 2020
Reviewer #4 agreed
On 18 Jun, 2020
Editor assigned
On 17 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
Reviewer #1 agreed
On 17 Jun, 2020
Reviewer #2 agreed
On 17 Jun, 2020
Reviewer #3 agreed
On 17 Jun, 2020
First submitted
On 16 Jun, 2020
Submission checks complete
On 16 Jun, 2020
Editor invited
On 16 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Lipids in Health and Disease.
Background: In this study, we aimed to investigate the dynamic changes of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain whether these changes were associated with the prognosis of the disease.
Methods: This retrospective study was conducted at a tertiary critical care center in China. We included sHTGP patients who were admitted within 72h after AP onset. All the sHTGP patients received DFPP within 24h after admission. Lipid profile changes was measured in 47 patients with sHTGP on admission, consecutive 4 days after DFPP and at discharge. According to the TG levels in the first day after DFPP, we divided patients into two group: non-target (TG>5.6mmol/L) and target group (TG ≤5.6mmol/L). Propensity score matching was used to investigate association between TG-lowering effect and the prognosis. Linear regression analysis on four models was used to determine the relationship between other lipid parameters and the outcome.
Results: Except for low density lipoprotein, all the parameters of lipid profile at disease onset showed significant difference from their normal levels. The median serum triglyceride (TG) level of the sHTGP patients was 42.9 mmol/L on admission. In the first day after DFPP, serum TG, cholesterol (TC) and very low density lipoprotein decreased significantly, and the high-density lipoprotein (HDL) as well as apoprotein A1 increased meanwhile. TG continued to fall for the following three days and the other indicators held steady. After propensity score matching, the hospitalization duration was significantly lower in the target group (14.5 [13.0, 16.0] vs 8.0 [6.0, 15.3], P=0.035). Linear regression analysis revealed that the levels of HDL were negatively associated with the duration of hospitalization in three adjusted models.
Conclusion: There was distinct fluctuation of the lipid profile upon the burst of sHTGP and the parameters changed significantly in the first day after DFPP. Among these parameters, HDL may serve as a biomarker for disease prognosis in patients with sHTGP. Moreover, reaching the TG-lowering target of 5.6mmol/L may shorten hospitalization duration.
Figure 1
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