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Research article
Jane Luise Hutton
The University of Warwick
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0963-9997
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Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.
Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation.
Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface.
Trial registration NCT01577147
Keywords
pregnancy, nausea, vomiting, onset, last menstrual period, luteinising hormone (LH) surge
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CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Version 2
Posted 12 Nov, 2020
No community comments so far
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On 04 Nov, 2020
Editorial decision: Minor revision
On 01 Nov, 2020
Version (no preprint)
Posted 23 Oct, 2020
Editorial decision: Minor revision
On 23 Oct, 2020
Reviewer #1 agreed
On 29 Sep, 2020
Reviewer #2 agreed
On 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Review #2 received
Received 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Reviewers invited
Invitations sent on 28 Sep, 2020
Editor invited
On 27 Sep, 2020
Submission checks complete
On 27 Sep, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 28 Aug, 2020
Reviewer #3 agreed
On 19 Aug, 2020
Reviewer #4 agreed
On 19 Aug, 2020
Review #2 received
Received 19 Aug, 2020
Review #3 received
Received 19 Aug, 2020
Reviewer #2 agreed
On 18 Aug, 2020
Review #1 received
Received 13 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Reviewers invited
Invitations sent on 27 Jul, 2020
Editor assigned
On 15 Jul, 2020
Submission checks complete
On 14 Jul, 2020
Editor invited
On 14 Jul, 2020
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Subject Areas
Maternal & Fetal Medicine
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A new preprint design is coming!
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See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jane Luise Hutton
The University of Warwick
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0963-9997
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Version 2
Posted 12 Nov, 2020
No community comments so far
Submission checks complete
On 04 Nov, 2020
Editorial decision: Minor revision
On 01 Nov, 2020
Version (no preprint)
Posted 23 Oct, 2020
Editorial decision: Minor revision
On 23 Oct, 2020
Reviewer #1 agreed
On 29 Sep, 2020
Reviewer #2 agreed
On 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Review #2 received
Received 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Reviewers invited
Invitations sent on 28 Sep, 2020
Editor invited
On 27 Sep, 2020
Submission checks complete
On 27 Sep, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 28 Aug, 2020
Reviewer #3 agreed
On 19 Aug, 2020
Reviewer #4 agreed
On 19 Aug, 2020
Review #2 received
Received 19 Aug, 2020
Review #3 received
Received 19 Aug, 2020
Reviewer #2 agreed
On 18 Aug, 2020
Review #1 received
Received 13 Aug, 2020
Reviewer #1 agreed
On 06 Aug, 2020
Reviewers invited
Invitations sent on 27 Jul, 2020
Editor assigned
On 15 Jul, 2020
Submission checks complete
On 14 Jul, 2020
Editor invited
On 14 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background Nausea and vomiting are experienced by most women during pregnancy. The onset is usually related to Last Menstrual Period (LMP) the date of which is often unreliable. This study describes the time to onset of nausea and vomiting symptoms from date of ovulation and compares this to date of last menstrual period Methods Prospective cohort of women seeking to become pregnant, recruited from 12 May 2014 to 25 November 2016, in the United Kingdom. Daily diaries of nausea and vomiting were kept by 256 women who were trying to conceive. The main outcome measure is the number of days from last menstrual period (LMP) or luteinising hormone surge until onset of nausea or vomiting.
Results Almost all women (88%) had Human Chorionic Gonadotrophin rise within 8 to 10 days of ovulation; the equivalent interval from LMP was 20 to 30 days. Many (67%) women experience symptoms within 11 to 20 days of ovulation.
Conclusions Onset of nausea and vomiting occurs earlier than previously reported and there is a narrow window for onset of symptoms. This indicates that its etiology is associated with a specific developmental stage at the foetal-maternal interface.
Trial registration NCT01577147
Figure 1
Figure 2
Figure 3
The full text of this article is available to read as a PDF.
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