According to the damage mechanics theory and Lemaitre strain equivalence theory, because most rock materials are brittle materials, Griffith strength criterion has good applicability to describe the fracture failure of brittle materials from the perspective of energy. Using a new method to describe the rock micro-element strength based on Griffith strength criterion, and assuming the micro-element strength obeys the Weibull distribution, a true triaxial constitutive model of damage softening reflecting the whole process of rock failure is established. On this basis, the influence of the two parameters in the model on the curve of the constitutive model is analyzed, and the relationship between the two parameters and the intermediate principal stress in the model is established, and the model is revised reasonably. Finally, a true triaxial damage constitutive model of rock is established. The results are in good agreement with the experimental curve, which verifies its validity and rationality. At the same time, the relationship between the damage evolution and the strain and stress is discussed, and the influence of the size of the intermediate principal stress on the relationship is analyzed in detail.