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Research Article
Hannah Pegram
DRG Abacus: DRG Bicester
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4446-4531
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This work is licensed under a CC BY 4.0 License. Read Full License
Purpose This study explored perceptions of meaningful weight-loss and the level of change on two patient-reported outcome (PRO) measures, the 36-item Short Form Health Survey® SF-36v2® and Impact of Weight on Quality of Life Lite-Clinical Trials © IWQOL-Lite-CT © , that individuals living with overweight or obesity consider to be meaningful and indicative of treatment success. Methods Thirty-three qualitative interviews were conducted in the US with adults living with overweight or obesity. Concept elicitation explored perceptions of minimally important/meaningful weight-loss using open-ended questions. Cognitive debriefing was used to understand thresholds for meaningful change on both measures. Results Most participants (n=23/33) expected a 5% total body weight-loss to yield some benefit in physical functioning, while all participants expected a 10% weight-loss to provide a meaningful and noticeable improvement in their physical functioning. Participants indicated that an item-level 1-point score change on each measure would represent a noticeable improvement in physical functioning and indicate treatment success. Conclusions Participants expected moderate weight losses to be noticeable, with ≥10% weight-loss yielding the most consistent results. The findings suggested that both measures provide strong opportunity to demonstrate treatment benefit in relation to physical functioning as a small change on the response scale would represent a noticeable improvement in participants’ daily lives.
Keywords
Adults, Obesity, Physical activity, Quality of life
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CURRENT STATUS: Under Review
Version 1
Posted 03 May, 2021
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Reviewers invited
Invitations sent on 29 Jun, 2021
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Received 29 Apr, 2021
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Quality of Life Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hannah Pegram
DRG Abacus: DRG Bicester
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4446-4531
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 03 May, 2021
No community comments so far
Reviewers invited
Invitations sent on 29 Jun, 2021
Reviews received
Received 29 Apr, 2021
Editor assigned
On 31 Mar, 2021
First submitted
On 31 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose This study explored perceptions of meaningful weight-loss and the level of change on two patient-reported outcome (PRO) measures, the 36-item Short Form Health Survey® SF-36v2® and Impact of Weight on Quality of Life Lite-Clinical Trials © IWQOL-Lite-CT © , that individuals living with overweight or obesity consider to be meaningful and indicative of treatment success. Methods Thirty-three qualitative interviews were conducted in the US with adults living with overweight or obesity. Concept elicitation explored perceptions of minimally important/meaningful weight-loss using open-ended questions. Cognitive debriefing was used to understand thresholds for meaningful change on both measures. Results Most participants (n=23/33) expected a 5% total body weight-loss to yield some benefit in physical functioning, while all participants expected a 10% weight-loss to provide a meaningful and noticeable improvement in their physical functioning. Participants indicated that an item-level 1-point score change on each measure would represent a noticeable improvement in physical functioning and indicate treatment success. Conclusions Participants expected moderate weight losses to be noticeable, with ≥10% weight-loss yielding the most consistent results. The findings suggested that both measures provide strong opportunity to demonstrate treatment benefit in relation to physical functioning as a small change on the response scale would represent a noticeable improvement in participants’ daily lives.
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