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Research Article
Jie Lin
HwaMei Hospital, University of Chinese Academy of Sciences
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: This is a study aimed at exploring the relationship between pretreatment overweight/obesity, adipose tissue distribution, and long-term prognosis of gastric cancer.
Methods: A total of 607 gastric cancer patients were involved in the retrospective cohort study. Overweight/obese patients was defined as body mass index (BMI) greater than 25 kg/m2 and adipose tissue distribution parameters, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio were measured at the level of the third lumbar vertebra using computerized tomography images within 15 days before the surgery. Multiple Cox regression models were applied to evaluate the association between overweight/obesity and disease-specific survival (DSS) of gastric cancer and covariates including age, gender, T stage, N stage, and chemotherapy were adjusted. Furthermore, multiple Cox regression models were performed to evaluate the association between adipose tissue distribution parameters and DSS of gastric cancer, expect for covariates mentioned above, overweight/obesity was adjusted additionally.
Results: Overweight/obesity was a protective factor (HR = 0.61, 95% CI: 0.37-0.99) for the prognosis of gastric cancer. While high SAT percentage was independently related to a good prognosis, high VAT percentage and high VAT/SAT ratio were independently related to poor prognosis of resectable gastric cancer.
Conclusion: These results suggest that overweight/obesity is a protective factor for the prognosis of gastric cancer. The VAT/SAT ratio could be used as a promising prognostic factor for gastric cancer. Therefore, in preoperative evaluation of gastric cancer patients, attention should be paid not only to BMI but also to adipose tissue distribution.
Keywords
overweight, obesity, adipose tissue distribution, gastric cancer, prognosis
Figure 1
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Figure 4
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- Figure.S1.tif
Figure S1. Optimal cutoff values of adipose tissue distribution parameters. (A) SAT percentage; (B) VAT percentage; (C) VAT/SAT Ratio. VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue.
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CURRENT STATUS: Under Revision
Version 1
Posted 21 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 31 May, 2021
Reviews received
Received 10 May, 2021
Reviewers agreed
On 26 Apr, 2021
Reviewers invited
Invitations sent on 25 Apr, 2021
Editor assigned
On 20 Apr, 2021
Editor invited
On 20 Apr, 2021
Submission checks complete
On 20 Apr, 2021
First submitted
On 02 Apr, 2021
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Subject Areas
Cancer Biology
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A new preprint design is coming!
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This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Jie Lin
HwaMei Hospital, University of Chinese Academy of Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 21 Apr, 2021
No community comments so far
Editorial decision: Major revision
On 31 May, 2021
Reviews received
Received 10 May, 2021
Reviewers agreed
On 26 Apr, 2021
Reviewers invited
Invitations sent on 25 Apr, 2021
Editor assigned
On 20 Apr, 2021
Editor invited
On 20 Apr, 2021
Submission checks complete
On 20 Apr, 2021
First submitted
On 02 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cancer Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This is a study aimed at exploring the relationship between pretreatment overweight/obesity, adipose tissue distribution, and long-term prognosis of gastric cancer.
Methods: A total of 607 gastric cancer patients were involved in the retrospective cohort study. Overweight/obese patients was defined as body mass index (BMI) greater than 25 kg/m2 and adipose tissue distribution parameters, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio were measured at the level of the third lumbar vertebra using computerized tomography images within 15 days before the surgery. Multiple Cox regression models were applied to evaluate the association between overweight/obesity and disease-specific survival (DSS) of gastric cancer and covariates including age, gender, T stage, N stage, and chemotherapy were adjusted. Furthermore, multiple Cox regression models were performed to evaluate the association between adipose tissue distribution parameters and DSS of gastric cancer, expect for covariates mentioned above, overweight/obesity was adjusted additionally.
Results: Overweight/obesity was a protective factor (HR = 0.61, 95% CI: 0.37-0.99) for the prognosis of gastric cancer. While high SAT percentage was independently related to a good prognosis, high VAT percentage and high VAT/SAT ratio were independently related to poor prognosis of resectable gastric cancer.
Conclusion: These results suggest that overweight/obesity is a protective factor for the prognosis of gastric cancer. The VAT/SAT ratio could be used as a promising prognostic factor for gastric cancer. Therefore, in preoperative evaluation of gastric cancer patients, attention should be paid not only to BMI but also to adipose tissue distribution.
Figure 1
Figure 2
Figure 3
Figure 4
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- Figure.S1.tif
Figure S1. Optimal cutoff values of adipose tissue distribution parameters. (A) SAT percentage; (B) VAT percentage; (C) VAT/SAT Ratio. VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue.
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