Coronaviruses are classified under the Coronaviridae family (order Nidovirales and subfamily Orthocoronavirinae). The subfamily of Orthocoronavirinae includes four genera: the alpha, beta, gamma and delta coronaviruses. Coronaviruses primarily can infect birds and mammals (eg. bats) but in the last decades, evidences have shown that they also have the capability of infecting the human (1). In late 2019, a novel flu-like coronavirus disease was discovered in Wuhan, China, which is relevant to the Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) coronaviruses. The virus can be transmitted through close human-to-human contact. Currently, the absence of a definitive treatment or a vaccine for this disease has been sensed (2). Fever, nonproductive cough, myalgia, dyspnea, fatigue, decreased leukocyte counts and pneumonia shown in radiographs are some of the clinical manifestations of the disease. Severe cases may encounter organ dysfunction (eg. shock, acute respiratory distress syndrome, acute cardiac injury and acute kidney injury) and death (3).
Inflammation of the meninges, the three membranes that cover the brain and the spinal cord, due to mycobacterial species is called Tuberculous Meningitis (TBM). TBM is indeed a severe form of TB and may cause death (4). Clinical manifestations of TBM include headache, fever, vomiting, altered conscious level and sometimes convulsions (5). Diagnosing TBM, even with advanced imaging techniques and anti-tuberculosis drugs is time-consuming and difficult because of its rarity; which is why the morbidity and mortality of TBM is still high (6).
Conversion disorder or functional neurological symptom disorder is a psychiatric disorder that results from a stressful event and the onset of the symptoms is sudden. The disease is characterized by a physical defect related to a neurological and psychological disorder (7). This conversion of psychiatric disorder to somatoform disorder (if other medical disorders are ruled out) is termed conversion disorder (8). This disorder is more common in women and young people, but it is not usually seen under the age of 10. The disorder is mainly caused by a stressful incident, rape, physical abuse, depression and anxiety (9). The patient’s common symptoms include blindness, dystonia, anesthesia, paralysis, difficulty in speaking, incontinence, balance problems, hallucinations and psychogenic non-epileptic seizures. The physician should be aware of differentiating the patients who are intentionally producing symptoms (which we can see in patients with factitious disorders and malingering) from the one who are really struggling with conversion disorder (10).
Postpartum depression is a serious psychological health problem that is prevalent during the postpartum period, especially in the first year after delivery (11). Maternal health, marital relationships and newborns can be affected by postpartum depression and if left untreated, these effects will last for a long time (12).
In a literature review, people’s mental health burden during the epidemic of COVID-19 was examined and it demonstrated that young people, people who are focused and concerned about the COVID-19 epidemic and healthcare workers were at a high risk for developing mental illness (13). In our literature, we intend to report a treatment-resistant tuberculous meningitis case who had become infected with COVID-19 and undergone several anxiety attacks. In fact, this is a rare and interesting case with comorbidities and complications.