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Background: To investigate the predictive value of the neutrophil-lymphocyte ratio (NLR), white blood cell-lymphocyte ratio (WLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) in grading the malignant potential of the gastrointestinal stromal tumour (GIST).
Methods: We retrospectively reviewed 843 GIST patients who underwent surgery during hospitalisation from June 2016 to July 2020 and 374 unrelated healthy controls. Demographic data were collected for each participant, including age, gender, body mass index, laboratory test results, and pathological results. We compared the NLR, WLR, MLR, and PLR between GIST and healthy individuals, as well as among patients with different risk grades of GIST.
Results: NLR, WLR, MLR, and PLR values of patients with GIST were significantly increased compared with those of the control group (P<0.05). These values also showed statistically significant differences among the four risk degree groups. The NLR, WLR, MLR, and PLR values of the high-risk group were significantly higher than those of the very low-risk group, low-risk group, and intermediate-risk group (p<0.001). The NLR, WLR, MLR, and PLR showed a high predictive value in the high-risk group, with an area under the receiver operating characteristic curve of 0.802, 0.824, 0.866, and 0.814, and a cut-off value of 2.059, 3.347, 0.221, and 141.4, respectively.
Conclusion: Preoperative NLR, WLR, MLR, and PLR have a high predictive value for grading the malignant potential of GIST, especially in the high-risk group. These values provide a convenient and inexpensive way to determine preoperative chemotherapy and surgical strategies.
Keywords
Gastrointestinal stromal tumour, Neutrophil-lymphocyte rate, White blood cell-lymphocyte rate, Monocyte-lymphocyte rate, Platelet-lymphocyte rate
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CURRENT STATUS: Under Review
Version 1
Posted 05 Apr, 2021
No community comments so far
Review #1 received
Received 03 Feb, 2021
Reviewer #1 agreed
On 31 Jan, 2021
Reviewers invited
Invitations sent on 30 Jan, 2021
Editor assigned
On 12 Jan, 2021
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On 12 Jan, 2021
Editor invited
On 12 Jan, 2021
First submitted
On 21 Dec, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 05 Apr, 2021
No community comments so far
Review #1 received
Received 03 Feb, 2021
Reviewer #1 agreed
On 31 Jan, 2021
Reviewers invited
Invitations sent on 30 Jan, 2021
Editor assigned
On 12 Jan, 2021
Submission checks complete
On 12 Jan, 2021
Editor invited
On 12 Jan, 2021
First submitted
On 21 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To investigate the predictive value of the neutrophil-lymphocyte ratio (NLR), white blood cell-lymphocyte ratio (WLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) in grading the malignant potential of the gastrointestinal stromal tumour (GIST).
Methods: We retrospectively reviewed 843 GIST patients who underwent surgery during hospitalisation from June 2016 to July 2020 and 374 unrelated healthy controls. Demographic data were collected for each participant, including age, gender, body mass index, laboratory test results, and pathological results. We compared the NLR, WLR, MLR, and PLR between GIST and healthy individuals, as well as among patients with different risk grades of GIST.
Results: NLR, WLR, MLR, and PLR values of patients with GIST were significantly increased compared with those of the control group (P<0.05). These values also showed statistically significant differences among the four risk degree groups. The NLR, WLR, MLR, and PLR values of the high-risk group were significantly higher than those of the very low-risk group, low-risk group, and intermediate-risk group (p<0.001). The NLR, WLR, MLR, and PLR showed a high predictive value in the high-risk group, with an area under the receiver operating characteristic curve of 0.802, 0.824, 0.866, and 0.814, and a cut-off value of 2.059, 3.347, 0.221, and 141.4, respectively.
Conclusion: Preoperative NLR, WLR, MLR, and PLR have a high predictive value for grading the malignant potential of GIST, especially in the high-risk group. These values provide a convenient and inexpensive way to determine preoperative chemotherapy and surgical strategies.
Figure 1
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