This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Guotai Sheng
Jiangxi Provincial People's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5298-4724
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Previous studies have shown that both C-reactive protein (CRP) and albumin (Alb) are the prognostic factors of cardiovascular. However, the prognostic value of C-reactive protein to albumin ratio (CAR) in patients with stable coronary artery disease (SCAD) is unclear.
Methods
This was a retrospective cohort study that continuously enrolled 204 patients with newly diagnosed SCAD between October 2014 and October 2017; the mean follow-up time was 793.75 ± 430.26 days. The Cox proportional hazard model was used to evaluate the prognostic value of CAR in patients with SCAD.
Results
In the Kaplan–Meier analysis, the long-term MACE (major adverse cardiac events) free survival rate of patients with high CAR levels decreased significantly (P = 0.015). Of the note, after adjusting for other covariates in multivariate analysis, CAR was still independently positively correlated with poor prognosis in SCAD patients (HR = 1.03, 95% CI:1.01–1.06, P = 0.02, P for trend = 0.024). Additionally, we identified a nonlinear association between CAR and poor prognosis of SCAD by the generalized additive model (GAM). Then, through the two-piecewise linear regression model, we calculated that the inflection point of CAR was 3.933 (log-likelihood ratio test P = 0.02). When CAR ≤ 3.933, there was a positive correlation between CAR and MACE in patients with SCAD (HR:1.48, 95% CI:1.10–1.99, P = 0.009). While on the right hand of the inflection point (CAR > 3.933), the positive correlation between the two tends to be saturated (HR:1.01, 95% CI:0.97–1.05, P = 0.64).
Conclusions
This study indicated an association between higher CAR levels and increased risk of MACE in patients with SCAD for the first time, and measurement of CAR at admission may be a valuable predictor of the prognostic outcome in patients with SCAD treated by the percutaneous coronary intervention.
Keywords
C-reactive protein to albumin ratio, stable coronary artery disease, C-reactive protein, albumin, percutaneous coronary intervention
Figure 1
Figure 2
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 30 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Guotai Sheng
Jiangxi Provincial People's Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5298-4724
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 30 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Previous studies have shown that both C-reactive protein (CRP) and albumin (Alb) are the prognostic factors of cardiovascular. However, the prognostic value of C-reactive protein to albumin ratio (CAR) in patients with stable coronary artery disease (SCAD) is unclear.
Methods
This was a retrospective cohort study that continuously enrolled 204 patients with newly diagnosed SCAD between October 2014 and October 2017; the mean follow-up time was 793.75 ± 430.26 days. The Cox proportional hazard model was used to evaluate the prognostic value of CAR in patients with SCAD.
Results
In the Kaplan–Meier analysis, the long-term MACE (major adverse cardiac events) free survival rate of patients with high CAR levels decreased significantly (P = 0.015). Of the note, after adjusting for other covariates in multivariate analysis, CAR was still independently positively correlated with poor prognosis in SCAD patients (HR = 1.03, 95% CI:1.01–1.06, P = 0.02, P for trend = 0.024). Additionally, we identified a nonlinear association between CAR and poor prognosis of SCAD by the generalized additive model (GAM). Then, through the two-piecewise linear regression model, we calculated that the inflection point of CAR was 3.933 (log-likelihood ratio test P = 0.02). When CAR ≤ 3.933, there was a positive correlation between CAR and MACE in patients with SCAD (HR:1.48, 95% CI:1.10–1.99, P = 0.009). While on the right hand of the inflection point (CAR > 3.933), the positive correlation between the two tends to be saturated (HR:1.01, 95% CI:0.97–1.05, P = 0.64).
Conclusions
This study indicated an association between higher CAR levels and increased risk of MACE in patients with SCAD for the first time, and measurement of CAR at admission may be a valuable predictor of the prognostic outcome in patients with SCAD treated by the percutaneous coronary intervention.
Figure 1
Figure 2
Loading...