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Research article
Anna Maria Cattelan
Azienda Ospedaliera di Padova
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2869-2945
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Identifying risk factors for severe novel-coronavirus disease (COVID-19) is essential to ascertain which patients may benefit from advanced supportive care. The study aims to give a comparative description of COVID-19 patients who were admitted or not to the intensive (ICU) or sub-intensive cares units (SICU).
Methods
This observational study of prospectively collected data included all COVID-19 patients primarily admitted to the Infectious Diseases department of Padua between February 22 and May 20, 2020. Clinical, laboratory, radiological and treatment data were collected. The primary outcome was a composite of ICU and/or SICU admission.
Results
303 patients were included. Median age was 62 years (IQR:50-74), 60.1% were male. 234 patients were managed in the Infectious Diseases ward (Group 1) and 69 patients (22,8%) met the primary outcome (Group 2). The mortality rate was 6.8%. Group 2 were more likely to be men, had a higher mortality (14,5%vs3,8%, p<0,01) and had more hypertension (72,4vs 44%,p<0,01) and diabetes (31,9vs21%,p=0,04). Chest X-ray at admission was positive in 63,2% and Group 2 were more likely to develop pathological findings during the hospitalization (72,7%vs17,2%,p<0,01). Group 2 presented at admission a higher neutrophil count, aspartate-transaminase and C-reactive-protein. At the 3° measurement, differences were found for white blood cell and neutrophil count, liver function tests and C-reactive-protein. Group 1 presented a shorter duration from admission to negativization of follow-up swabs (20vs35days,p<0,01).
Conclusions
The presence of comorbidities and the persistent observation of slightly abnormal laboratory findings should be regarded as predisposing factors for disease severity and clinical worsening.
Keywords
COVID-19, SARS-CoV-2, novel coronavirus, disease severity, outcome, intensive care, sub-intensive care
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Submission checks complete
On 19 Nov, 2020
Editorial decision: Accept
On 18 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Review #2 received
Received 23 Oct, 2020
Reviewer #2 agreed
On 09 Oct, 2020
Review #1 received
Received 03 Oct, 2020
Reviewers invited
Invitations sent on 02 Oct, 2020
Reviewer #1 agreed
On 02 Oct, 2020
Editor assigned
On 01 Oct, 2020
Submission checks complete
On 30 Sep, 2020
Editor invited
On 30 Sep, 2020
Version 1
Posted 15 Jul, 2020
No comments provided
Editorial decision: Major revision
On 07 Sep, 2020
Review #2 received
Received 03 Sep, 2020
Review #1 received
Received 26 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #1 agreed
On 30 Jul, 2020
Reviewers invited
Invitations sent on 26 Jul, 2020
Editor assigned
On 03 Jul, 2020
First submitted
On 02 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
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A new preprint design is coming!
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See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Anna Maria Cattelan
Azienda Ospedaliera di Padova
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2869-2945
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Submission checks complete
On 19 Nov, 2020
Editorial decision: Accept
On 18 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 28 Oct, 2020
Review #2 received
Received 23 Oct, 2020
Reviewer #2 agreed
On 09 Oct, 2020
Review #1 received
Received 03 Oct, 2020
Reviewers invited
Invitations sent on 02 Oct, 2020
Reviewer #1 agreed
On 02 Oct, 2020
Editor assigned
On 01 Oct, 2020
Submission checks complete
On 30 Sep, 2020
Editor invited
On 30 Sep, 2020
Version 1
Posted 15 Jul, 2020
No comments provided
Editorial decision: Major revision
On 07 Sep, 2020
Review #2 received
Received 03 Sep, 2020
Review #1 received
Received 26 Aug, 2020
Reviewer #2 agreed
On 17 Aug, 2020
Reviewer #1 agreed
On 30 Jul, 2020
Reviewers invited
Invitations sent on 26 Jul, 2020
Editor assigned
On 03 Jul, 2020
First submitted
On 02 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background
Identifying risk factors for severe novel-coronavirus disease (COVID-19) is essential to ascertain which patients may benefit from advanced supportive care. The study aims to give a comparative description of COVID-19 patients who were admitted or not to the intensive (ICU) or sub-intensive cares units (SICU).
Methods
This observational study of prospectively collected data included all COVID-19 patients primarily admitted to the Infectious Diseases department of Padua between February 22 and May 20, 2020. Clinical, laboratory, radiological and treatment data were collected. The primary outcome was a composite of ICU and/or SICU admission.
Results
303 patients were included. Median age was 62 years (IQR:50-74), 60.1% were male. 234 patients were managed in the Infectious Diseases ward (Group 1) and 69 patients (22,8%) met the primary outcome (Group 2). The mortality rate was 6.8%. Group 2 were more likely to be men, had a higher mortality (14,5%vs3,8%, p<0,01) and had more hypertension (72,4vs 44%,p<0,01) and diabetes (31,9vs21%,p=0,04). Chest X-ray at admission was positive in 63,2% and Group 2 were more likely to develop pathological findings during the hospitalization (72,7%vs17,2%,p<0,01). Group 2 presented at admission a higher neutrophil count, aspartate-transaminase and C-reactive-protein. At the 3° measurement, differences were found for white blood cell and neutrophil count, liver function tests and C-reactive-protein. Group 1 presented a shorter duration from admission to negativization of follow-up swabs (20vs35days,p<0,01).
Conclusions
The presence of comorbidities and the persistent observation of slightly abnormal laboratory findings should be regarded as predisposing factors for disease severity and clinical worsening.
This is a list of supplementary files associated with this preprint. Click to download.
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