See the published version of this article at Radiation Oncology.
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zhen zhang
Fudan University Shanghai Cancer Center
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Radiation Oncology.
Background
Treatment for locally recurrent rectal cancer after surgery is still a challenge. With the physical and biological advantages, carbon-ion radiotherapy (CIRT) could be a choice for these patients. The purpose of this study was to investigate the efficacy and safety of CIRT for unresectable locally recurrent rectal cancer in Chinese patients.
Methods
Date from 25 patients with unresectable locally recurrent rectal cancer treated by CIRT from July 2015 to April 2019 were analyzed retrospectively. The endpoints of this study were overall survival (OS), local control (LC) and acute and late toxicity.
Results
With the median follow-up of 19.6 (range 5.1–52.5) months, data of all 25 patients were collected. Median prescribed dose for tumor was 72 Gy (relative biologic efficacy (RBE)) (range 48-75.6 Gy (RBE)). The LC rates at 1 and 2 years were 90.4% and 71.8%. Overall LC at 1- and 2-year were 76.2% and 30.5% for 9 patients whose prescribed tumor doses of CIRT < 66 Gy (RBE), 100% and 100% for 16 patients whose prescribed doses of CIRT ≥ 66 Gy (RBE). Patients received ≥ 66 Gy (RBE) had obviously better LC rates than those received < 66 Gy (RBE) (P = 0.001). The OS rates at 1 and 2 years were 82.9% and 65.1%, respectively. No acute toxicity over grade 2 was observed, grade 3 late toxicity were observed in 3 patients: gastrointestinal toxicity (n = 1), neuropathy (n = 1), pelvic infection (n = 1). No Grade 4 or higher toxicity was observed.
Conclusion
Our study shows that CIRT is effective for unresectable locally recurrent rectal cancer patients with acceptable toxicity.
Keywords
carbon-ion, rectal cancer, pelvic radiation, local recurrence, particle therapy
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CURRENT STATUS: Published
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Posted 01 Jul, 2020
Published
On 28 Aug, 2020
No community comments so far
Editorial decision: Minor revision
On 04 Aug, 2020
Review #2 received
Received 03 Aug, 2020
Reviewer #2 agreed
On 02 Aug, 2020
Review #1 received
Received 30 Jul, 2020
Reviewer #1 agreed
On 18 Jul, 2020
Reviewers invited
Invitations sent on 29 Jun, 2020
Editor assigned
On 28 Jun, 2020
Submission checks complete
On 27 Jun, 2020
Editor invited
On 27 Jun, 2020
First submitted
On 25 Jun, 2020
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This preprint is under consideration at Radiation Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
zhen zhang
Fudan University Shanghai Cancer Center
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 01 Jul, 2020
Published
On 28 Aug, 2020
No community comments so far
Editorial decision: Minor revision
On 04 Aug, 2020
Review #2 received
Received 03 Aug, 2020
Reviewer #2 agreed
On 02 Aug, 2020
Review #1 received
Received 30 Jul, 2020
Reviewer #1 agreed
On 18 Jul, 2020
Reviewers invited
Invitations sent on 29 Jun, 2020
Editor assigned
On 28 Jun, 2020
Submission checks complete
On 27 Jun, 2020
Editor invited
On 27 Jun, 2020
First submitted
On 25 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Radiation Oncology.
Background
Treatment for locally recurrent rectal cancer after surgery is still a challenge. With the physical and biological advantages, carbon-ion radiotherapy (CIRT) could be a choice for these patients. The purpose of this study was to investigate the efficacy and safety of CIRT for unresectable locally recurrent rectal cancer in Chinese patients.
Methods
Date from 25 patients with unresectable locally recurrent rectal cancer treated by CIRT from July 2015 to April 2019 were analyzed retrospectively. The endpoints of this study were overall survival (OS), local control (LC) and acute and late toxicity.
Results
With the median follow-up of 19.6 (range 5.1–52.5) months, data of all 25 patients were collected. Median prescribed dose for tumor was 72 Gy (relative biologic efficacy (RBE)) (range 48-75.6 Gy (RBE)). The LC rates at 1 and 2 years were 90.4% and 71.8%. Overall LC at 1- and 2-year were 76.2% and 30.5% for 9 patients whose prescribed tumor doses of CIRT < 66 Gy (RBE), 100% and 100% for 16 patients whose prescribed doses of CIRT ≥ 66 Gy (RBE). Patients received ≥ 66 Gy (RBE) had obviously better LC rates than those received < 66 Gy (RBE) (P = 0.001). The OS rates at 1 and 2 years were 82.9% and 65.1%, respectively. No acute toxicity over grade 2 was observed, grade 3 late toxicity were observed in 3 patients: gastrointestinal toxicity (n = 1), neuropathy (n = 1), pelvic infection (n = 1). No Grade 4 or higher toxicity was observed.
Conclusion
Our study shows that CIRT is effective for unresectable locally recurrent rectal cancer patients with acceptable toxicity.
Figure 1
Figure 2
Figure 3
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