1 J. Cortes, J.M. Perez-García, A. Llombart-Cussac, G. Curigliano, N.S. El Saghir, F. Cardoso, C.H. Barrios, S. Wagle, J. Roman, N. Harbeck, A. Eniu, P.A. Kaufman, J. Tabernero, L. García-Estévez, P. Schmid, and J. Arribas, Enhancing global access to cancer medicines. CA Cancer J Clin 70 (2020) 105-124.
2 Y. van der Pol, and F. Mouliere, Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA. Cancer Cell 36 (2019) 350-368.
3 T. Hu, J. Wolfram, and S. Srivastava, Extracellular Vesicles in Cancer Detection: Hopes and Hypes. Trends Cancer S2405-8033 (2020) 30257-0.
4 P.G. Pilié, C. Tang, G.B. Mills, and T.A. Yap, State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol 16 (2019) 81-104.
5 J. Mateo, C.J. Lord, V. Serra, A. Tutt, J. Balmaña, M. Castroviejo-Bermejo, C. Cruz, A. Oaknin, S.B. Kaye, and J.S. de Bono, A decade of clinical development of PARP inhibitors in perspective. Ann Oncol 30 (2019) 1437-1447.
6 Y. Okugawa, W.M. Grady, and A. Goel, Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology 149 (2015) 1204-1225.e12.
7 M. Acunzo, G. Romano, D. Wernicke, and C.M. Croce, MicroRNA and cancer--a brief overview. Adv Biol Regul 57 (2015) 1-9.
8 J.J. Chan, and Y. Tay, Noncoding RNA:RNA Regulatory Networks in Cancer. Int J Mol Sci 19 (2018) 1310.
9 J.N. Anastas, and R.T. Moon, WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 13 (2013) 11-26.
10 C. Vicente-Dueñas, J. Hauer, C. Cobaleda, A. Borkhardt, and I. Sánchez-García, Epigenetic Priming in Cancer Initiation. Trends Cancer 4 (2018) 408-417.
11 H. Shi, P. Chai, R. Jia, and X. Fan, Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation. Molecular cancer 19 (2020) 78.
12 R.J. Liu, T. Long, J. Li, H. Li, and E.D. Wang, Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. Nucleic acids research 45 (2017) 6684-6697.
13 R. García-Vílchez, A. Sevilla, and S. Blanco, Post-transcriptional regulation by cytosine-5 methylation of RNA. Biochim Biophys Acta Gene Regul Mech 1862 (2019) 240-252.
14 M. Frye, and S. Blanco, Post-transcriptional modifications in development and stem cells. Development 143 (2016) 3871-3881.
15 Z. Dong, and H. Cui, The Emerging Roles of RNA Modifications in Glioblastoma. Cancers (Basel) 12 (2020) 736.
16 L. Trixl, and A. Lusser, The dynamic RNA modification 5-methylcytosine and its emerging role as an epitranscriptomic mark. Wiley Interdiscip Rev RNA 10 (2019) e1510.
17 J. Catania, and D.S. Fairweather, DNA methylation and cellular ageing. Mutat Res 256 (1991) 283-93.
18 K.E. Bohnsack, C. Höbartner, and M.T. Bohnsack, Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease. Genes (Basel) 10 (2019) 102.
19 T. Yang, J.J.A. Low, and E.C.Y. Woon, A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells. Nucleic Acids Res 48 (2020) e5.
20 X. Yang, Y. Yang, B.F. Sun, Y.S. Chen, J.W. Xu, W.Y. Lai, A. Li, X. Wang, D.P. Bhattarai, W. Xiao, H.Y. Sun, Q. Zhu, H.L. Ma, S. Adhikari, M. Sun, Y.J. Hao, B. Zhang, C.M. Huang, N. Huang, G.B. Jiang, Y.L. Zhao, H.L. Wang, Y.P. Sun, and Y.G. Yang, 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader. Cell Res 27 (2017) 606-625.
21 L. Dou, X. Li, H. Ding, L. Xu, and H. Xiang, Prediction of m5C Modifications in RNA Sequences by Combining Multiple Sequence Features. Mol Ther Nucleic Acids 21 (2020) 332-342.
22 M.A. Gama-Sosa, V.A. Slagel, R.W. Trewyn, R. Oxenhandler, K.C. Kuo, C.W. Gehrke, and M. Ehrlich, The 5-methylcytosine content of DNA from human tumors. Nucleic acids research 11 (1983) 6883-94.
23 H. Wu, and Y. Zhang, Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 25 (2011) 2436-52.
24 R. Reid, P.J. Greene, and D.V. Santi, Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. Nucleic Acids Res 27 (1999) 3138-45.
25 S. Hua, Y. Quan, M. Zhan, H. Liao, Y. Li, and L. Lu, miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1. Cancer Cell Int 19 (2019) 203.
26 Q. Zhou, L.Q. Zhou, S.H. Li, Y.W. Yuan, L. Liu, J.L. Wang, D.Z. Wu, Y. Wu, and L. Xin, Identification of subtype-specific genes signature by WGCNA for prognostic prediction in diffuse type gastric cancer. Aging (Albany NY) 12 (2020) 17418-17435.
27 D. Szklarczyk, J.H. Morris, H. Cook, M. Kuhn, S. Wyder, M. Simonovic, A. Santos, N.T. Doncheva, A. Roth, P. Bork, L.J. Jensen, and C. von Mering, The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res 45 (2017) D362-d368.
28 H. Zhou, L. Chen, Y. Lei, T. Li, H. Li, and X. Cheng, Integrated analysis of tumor mutation burden and immune infiltrates in endometrial cancer. Curr Probl Cancer (2020) 100660.
29 A.L. Barabási, N. Gulbahce, and J. Loscalzo, Network medicine: a network-based approach to human disease. Nat Rev Genet 12 (2011) 56-68.
30 S. Panneerdoss, V.K. Eedunuri, P. Yadav, S. Timilsina, S. Rajamanickam, S. Viswanadhapalli, N. Abdelfattah, B.C. Onyeagucha, X. Cui, Z. Lai, T.A. Mohammad, Y.K. Gupta, T.H. Huang, Y. Huang, Y. Chen, and M.K. Rao, Cross-talk among writers, readers, and erasers of m(6)A regulates cancer growth and progression. Sci Adv 4 (2018) eaar8263.
31 Y. He, X. Yu, J. Li, Q. Zhang, Q. Zheng, and W. Guo, Role of m(5)C-related regulatory genes in the diagnosis and prognosis of hepatocellular carcinoma. American journal of translational research 12 (2020) 912-922.
32 H.A. Abdel-Hafiz, and K.B. Horwitz, Role of epigenetic modifications in luminal breast cancer. Epigenomics 7 (2015) 847-62.
33 P. Costa-Pinheiro, D. Montezuma, R. Henrique, and C. Jerónimo, Diagnostic and prognostic epigenetic biomarkers in cancer. Epigenomics 7 (2015) 1003-15.
34 Y. Wang, R. Zhang, D. Wu, Z. Lu, W. Sun, Y. Cai, C. Wang, and J. Jin, Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. J Exp Clin Cancer Res 32 (2013) 8.
35 Y. Cheng, C. He, M. Wang, X. Ma, F. Mo, S. Yang, J. Han, and X. Wei, Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther 4 (2019) 62.
36 B.J. Wouters, and R. Delwel, Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia. Blood 127 (2016) 42-52.
37 A.B. Iniguez, G. Alexe, E.J. Wang, G. Roti, S. Patel, L. Chen, S. Kitara, A. Conway, A.L. Robichaud, B. Stolte, P. Bandopadhayay, A. Goodale, S. Pantel, Y. Lee, D.M. Cheff, M.D. Hall, R. Guha, M.I. Davis, M. Menard, N. Nasholm, W.A. Weiss, J. Qi, R. Beroukhim, F. Piccioni, C. Johannessen, and K. Stegmaier, Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling. Cancer Cell 34 (2018) 922-938.e7.
38 F. Atrian, and S.A. Lelièvre, Mining the epigenetic landscape of tissue polarity in search of new targets for cancer therapy. Epigenomics 7 (2015) 1313-25.
39 R. Hashizume, Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma. Neurol Med Chir (Tokyo) 57 (2017) 331-342.
40 I. Estibariz, A. Overmann, F. Ailloud, J. Krebes, C. Josenhans, and S. Suerbaum, The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori. Nucleic Acids Res 47 (2019) 2336-2348.
41 S. Saghafinia, M. Mina, N. Riggi, D. Hanahan, and G. Ciriello, Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors. Cell Rep 25 (2018) 1066-1080.e8.
42 Q. Zhang, Y. He, N. Luo, S.J. Patel, Y. Han, R. Gao, M. Modak, S. Carotta, C. Haslinger, D. Kind, G.W. Peet, G. Zhong, S. Lu, W. Zhu, Y. Mao, M. Xiao, M. Bergmann, X. Hu, S.P. Kerkar, A.B. Vogt, S. Pflanz, K. Liu, J. Peng, X. Ren, and Z. Zhang, Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma. Cell 179 (2019) 829-845.e20.
43 J.W.T. Tse, L.J. Jenkins, F. Chionh, and J.M. Mariadason, Aberrant DNA Methylation in Colorectal Cancer: What Should We Target? Trends Cancer 3 (2017) 698-712.
44 T. Sibbritt, H.R. Patel, and T. Preiss, Mapping and significance of the mRNA methylome. Wiley Interdiscip Rev RNA 4 (2013) 397-422.
45 M.C. Popis, S. Blanco, and M. Frye, Posttranscriptional methylation of transfer and ribosomal RNA in stress response pathways, cell differentiation, and cancer. Curr Opin Oncol 28 (2016) 65-71.
46 L. Lu, G. Zhu, H. Zeng, Q. Xu, and K. Holzmann, High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma. Cancer Invest 36 (2018) 246-253.
47 X. Cui, Z. Liang, L. Shen, Q. Zhang, S. Bao, Y. Geng, B. Zhang, V. Leo, L.A. Vardy, T. Lu, X. Gu, and H. Yu, 5-Methylcytosine RNA Methylation in Arabidopsis Thaliana. Mol Plant 10 (2017) 1387-1399.
48 S. Haag, A.S. Warda, J. Kretschmer, M.A. Günnigmann, C. Höbartner, and M.T. Bohnsack, NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. Rna 21 (2015) 1532-43.
49 L. Van Haute, S.Y. Lee, B.J. McCann, C.A. Powell, D. Bansal, L. Vasiliauskaitė, C. Garone, S. Shin, J.S. Kim, M. Frye, J.G. Gleeson, E.A. Miska, H.W. Rhee, and M. Minczuk, NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. Nucleic Acids Res 47 (2019) 8720-8733.
50 M. Janin, V. Ortiz-Barahona, M.C. de Moura, A. Martínez-Cardús, P. Llinàs-Arias, M. Soler, D. Nachmani, J. Pelletier, U. Schumann, M.E. Calleja-Cervantes, S. Moran, S. Guil, A. Bueno-Costa, D. Piñeyro, M. Perez-Salvia, M. Rosselló-Tortella, L. Piqué, J.J. Bech-Serra, C. De La Torre, A. Vidal, M. Martínez-Iniesta, J.F. Martín-Tejera, A. Villanueva, A. Arias, I. Cuartas, A.M. Aransay, A.M. La Madrid, A.M. Carcaboso, V. Santa-Maria, J. Mora, A.F. Fernandez, M.F. Fraga, I. Aldecoa, L. Pedrosa, F. Graus, N. Vidal, F. Martínez-Soler, A. Tortosa, C. Carrato, C. Balañá, M.W. Boudreau, P.J. Hergenrother, P. Kötter, K.D. Entian, J. Hench, S. Frank, S. Mansouri, G. Zadeh, P.D. Dans, M. Orozco, G. Thomas, S. Blanco, J. Seoane, T. Preiss, P.P. Pandolfi, and M. Esteller, Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Acta Neuropathol 138 (2019) 1053-1074.
51 Q. Zhang, Q. Zheng, X. Yu, Y. He, and W. Guo, Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues. J Transl Med 18 (2020) 245.
52 Y. He, Q. Zhang, Q. Zheng, X. Yu, and W. Guo, Distinct 5-methylcytosine profiles of circular RNA in human hepatocellular carcinoma. Am J Transl Res 12 (2020) 5719-5729.
53 P. Li, Y. Xu, Q. Zhang, Y. Li, W. Jia, X. Wang, Z. Xie, J. Liu, D. Zhao, M. Shao, S. Chen, N. Mo, Z. Jiang, L. Li, R. Liu, W. Huang, L. Chang, S. Chen, H. Li, W. Zuo, J. Li, R. Zhang, and X. Yang, Evaluating the role of RAD52 and its interactors as novel potential molecular targets for hepatocellular carcinoma. Cancer Cell Int 19 (2019) 279.
54 E.D. Pleasance, R.K. Cheetham, P.J. Stephens, D.J. McBride, S.J. Humphray, C.D. Greenman, I. Varela, M.L. Lin, G.R. Ordóñez, G.R. Bignell, K. Ye, J. Alipaz, M.J. Bauer, D. Beare, A. Butler, R.J. Carter, L. Chen, A.J. Cox, S. Edkins, P.I. Kokko-Gonzales, N.A. Gormley, R.J. Grocock, C.D. Haudenschild, M.M. Hims, T. James, M. Jia, Z. Kingsbury, C. Leroy, J. Marshall, A. Menzies, L.J. Mudie, Z. Ning, T. Royce, O.B. Schulz-Trieglaff, A. Spiridou, L.A. Stebbings, L. Szajkowski, J. Teague, D. Williamson, L. Chin, M.T. Ross, P.J. Campbell, D.R. Bentley, P.A. Futreal, and M.R. Stratton, A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463 (2010) 191-6.
55 A.C. Krepischi, P.L. Pearson, and C. Rosenberg, Germline copy number variations and cancer predisposition. Future Oncol 8 (2012) 441-50.
56 X. Zhao, X. Liu, A. Zhang, H. Chen, Q. Huo, W. Li, R. Ye, Z. Chen, L. Liang, Q.A. Liu, J. Shen, X. Jin, W. Li, M. Nygaard, X. Liu, Y. Hou, T. Ni, L. Bolund, W. Gottschalk, W. Tao, J. Gu, X.L. Tian, H. Yang, J. Wang, X. Xu, M.W. Lutz, J. Min, Y. Zeng, and C. Nie, The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY) 10 (2018) 1206-1222.
57 J. Fan, K. Wang, X. Du, J. Wang, S. Chen, Y. Wang, M. Shi, L. Zhang, X. Wu, D. Zheng, C. Wang, L. Wang, B. Tian, G. Li, Y. Zhou, and H. Cheng, ALYREF links 3'-end processing to nuclear export of non-polyadenylated mRNAs. The EMBO journal 38 (2019) e99910.