This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research
Fatemeh Mirzaee
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background and Objectives: Obesity has reached epidemic proportions globally. Among several methods for treating obesity, the use of dietary supplements is common recently. One supplement that can help in this regard might be vitamin B6 in high doses.The objective of this study was to evaluate the efficacy of pyridoxine hydrochloride supplementation on anthropometric measurements, body composition, visceral adiposity index and metabolic status in obese and overweight women.
Methods and Study Design: In this randomized controlled clinical trial, 44 obese and overweight women aged 18–50 years were selected and divided randomly into two groups: an intervention group (receiving 80 mg pyridoxine hydrochloride supplement for 8 weeks) and control group (receiving placebo for 8 weeks).
Results: In the pyridoxine hydrochloride group, weight(p=0.01), body mass index(p=0.009), fat mass(p=0.003), waist circumference(p=0.005), visceral adiposity index(p=0.001), fasting insulin, Insulin Resistance(HOMA-IR), Total cholesterol, low density lipoprotein(LDL), Triglycerides (TG) and leptin(p<0.001) decreased whereas adiponectin(p<0.001) increased in comparison to the baseline values. There was a significant difference in fat mass, visceral adiposity index, fasting insulin, HOMA-IR and TG between pyridoxine hydrochloride and control groups following intervention in adjusted models(p<0.05).
Conclusions: The findings suggest that vitamin B6 supplementation may be effective in reducing BMI and improving body composition and biochemical factors associated with obesity.
Trial registration: Iran Clinical Trials Registry: IRCT20181002041206N1. Registered on 31 October 2018, https://en.irct.ir/trial/34220.
Keywords
vitaminB6, body composition, adipocytokine, glycemic indices, lipid profile, excessive body weight.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 2
Posted 08 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 25 Jul, 2021
Review #2 received
Received 25 Jul, 2021
Reviews received
Received 14 Jul, 2021
Reviewer #2 agreed
On 13 Jul, 2021
Review #1 received
Received 16 Mar, 2021
Reviewer #1 agreed
On 01 Mar, 2021
Reviewers invited
Invitations sent on 28 Feb, 2021
Editor assigned
On 18 Feb, 2021
Submission checks complete
On 18 Feb, 2021
First submitted
On 23 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Fatemeh Mirzaee
Ahvaz Jundishapur University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 2
Posted 08 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 25 Jul, 2021
Review #2 received
Received 25 Jul, 2021
Reviews received
Received 14 Jul, 2021
Reviewer #2 agreed
On 13 Jul, 2021
Review #1 received
Received 16 Mar, 2021
Reviewer #1 agreed
On 01 Mar, 2021
Reviewers invited
Invitations sent on 28 Feb, 2021
Editor assigned
On 18 Feb, 2021
Submission checks complete
On 18 Feb, 2021
First submitted
On 23 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background and Objectives: Obesity has reached epidemic proportions globally. Among several methods for treating obesity, the use of dietary supplements is common recently. One supplement that can help in this regard might be vitamin B6 in high doses.The objective of this study was to evaluate the efficacy of pyridoxine hydrochloride supplementation on anthropometric measurements, body composition, visceral adiposity index and metabolic status in obese and overweight women.
Methods and Study Design: In this randomized controlled clinical trial, 44 obese and overweight women aged 18–50 years were selected and divided randomly into two groups: an intervention group (receiving 80 mg pyridoxine hydrochloride supplement for 8 weeks) and control group (receiving placebo for 8 weeks).
Results: In the pyridoxine hydrochloride group, weight(p=0.01), body mass index(p=0.009), fat mass(p=0.003), waist circumference(p=0.005), visceral adiposity index(p=0.001), fasting insulin, Insulin Resistance(HOMA-IR), Total cholesterol, low density lipoprotein(LDL), Triglycerides (TG) and leptin(p<0.001) decreased whereas adiponectin(p<0.001) increased in comparison to the baseline values. There was a significant difference in fat mass, visceral adiposity index, fasting insulin, HOMA-IR and TG between pyridoxine hydrochloride and control groups following intervention in adjusted models(p<0.05).
Conclusions: The findings suggest that vitamin B6 supplementation may be effective in reducing BMI and improving body composition and biochemical factors associated with obesity.
Trial registration: Iran Clinical Trials Registry: IRCT20181002041206N1. Registered on 31 October 2018, https://en.irct.ir/trial/34220.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
Loading...