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Background: This study evaluated the impact of multifaceted NPS MedicineWise programs conducted in 2009 and 2015 that targeted general practitioners (GPs) to reduce unnecessary prescribing of proton pump inhibitors (PPIs). Methods: Time series analyses was conducted of the dispensing rates of concessional PPI scripts between January 2006 and June 2016 using the Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) databases in Australia. Participants were GPs with dispensed PPI prescriptions to concessional patients between January 2006 and June 2016. The interventions were national NPS MedicineWise PPI educational programs in 2009 and 2015 delivered to all practising GPs in Australia. The 2015 intervention coincided with the release of Choosing Wisely Australia recommendations from the Royal Australian College of General Practitioners (RACGP). Outcome measures included monthly dispensing rates of high/standard and low strength PPIs prescribed by GPs among concessional patients in Australia. Results : Following the 2009 NPS MedicineWise program we observed a 6.7% reduction in the expected dispensing rate of standard strength PPIs among concessional patients between January 2006 and March 2015, and a total 8.6% reduction by June 2016 following the launch of the 2015 program. We observed a significant increase of 5.6% in the dispensing rate of low strength PPIs among concessional patients between April 2009 and March 2015, and no significant change in trend following the 2015 program. Conclusions: The NPS MedicineWise programs were associated with reductions in the dispensing rate of high/standard strength PPIs and with an increase in the dispensing rate of low-strength PPIs by June 2016 although a causal relation was not confirmed. Although the rate of high/standard strength PPI prescribing is declining, these formulations still constitute the majority of PPIs used in Australia. Regular interventions to sustain and improve PPI management by GPs may be warranted.
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CURRENT STATUS: Published
View the published article at BMC Primary Care.
Version 4
Posted 16 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 23 Apr, 2020
Review #1 received
Received 19 Mar, 2020
Reviewer #1 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 10 Mar, 2020
Editor assigned
On 09 Mar, 2020
Submission checks complete
On 08 Mar, 2020
Editor invited
On 08 Mar, 2020
No comments provided
Editorial decision: Revise before sending to peer reviewers
On 05 Mar, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 09 Dec, 2019
Review #1 received
Received 06 Dec, 2019
Reviewer #1 agreed
On 24 Nov, 2019
Reviewers invited
Invitations sent on 12 Nov, 2019
Editor assigned
On 21 Oct, 2019
Submission checks complete
On 20 Oct, 2019
Editor invited
On 20 Oct, 2019
No comments provided
Editorial decision: Minor revision
On 08 Oct, 2019
Review #1 received
Received 14 Sep, 2019
Review #2 received
Received 12 Sep, 2019
Reviewer #2 agreed
On 29 Aug, 2019
Reviewers invited
Invitations sent on 27 Aug, 2019
Reviewer #1 agreed
On 27 Aug, 2019
Submission checks complete
On 16 Aug, 2019
Editor invited
On 16 Aug, 2019
Editor assigned
On 26 Jul, 2019
First submitted
On 22 Jul, 2019
Metrics
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HTML Views: ...
Subject Areas
General Practice
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See the published version of this preprint at BMC Primary Care.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Primary Care.
Version 4
Posted 16 Mar, 2020
No community comments so far
Editorial decision: Minor revision
On 23 Apr, 2020
Review #1 received
Received 19 Mar, 2020
Reviewer #1 agreed
On 15 Mar, 2020
Reviewers invited
Invitations sent on 10 Mar, 2020
Editor assigned
On 09 Mar, 2020
Submission checks complete
On 08 Mar, 2020
Editor invited
On 08 Mar, 2020
No comments provided
Editorial decision: Revise before sending to peer reviewers
On 05 Mar, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 09 Dec, 2019
Review #1 received
Received 06 Dec, 2019
Reviewer #1 agreed
On 24 Nov, 2019
Reviewers invited
Invitations sent on 12 Nov, 2019
Editor assigned
On 21 Oct, 2019
Submission checks complete
On 20 Oct, 2019
Editor invited
On 20 Oct, 2019
No comments provided
Editorial decision: Minor revision
On 08 Oct, 2019
Review #1 received
Received 14 Sep, 2019
Review #2 received
Received 12 Sep, 2019
Reviewer #2 agreed
On 29 Aug, 2019
Reviewers invited
Invitations sent on 27 Aug, 2019
Reviewer #1 agreed
On 27 Aug, 2019
Submission checks complete
On 16 Aug, 2019
Editor invited
On 16 Aug, 2019
Editor assigned
On 26 Jul, 2019
First submitted
On 22 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Practice
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Primary Care.
Background: This study evaluated the impact of multifaceted NPS MedicineWise programs conducted in 2009 and 2015 that targeted general practitioners (GPs) to reduce unnecessary prescribing of proton pump inhibitors (PPIs). Methods: Time series analyses was conducted of the dispensing rates of concessional PPI scripts between January 2006 and June 2016 using the Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) databases in Australia. Participants were GPs with dispensed PPI prescriptions to concessional patients between January 2006 and June 2016. The interventions were national NPS MedicineWise PPI educational programs in 2009 and 2015 delivered to all practising GPs in Australia. The 2015 intervention coincided with the release of Choosing Wisely Australia recommendations from the Royal Australian College of General Practitioners (RACGP). Outcome measures included monthly dispensing rates of high/standard and low strength PPIs prescribed by GPs among concessional patients in Australia. Results : Following the 2009 NPS MedicineWise program we observed a 6.7% reduction in the expected dispensing rate of standard strength PPIs among concessional patients between January 2006 and March 2015, and a total 8.6% reduction by June 2016 following the launch of the 2015 program. We observed a significant increase of 5.6% in the dispensing rate of low strength PPIs among concessional patients between April 2009 and March 2015, and no significant change in trend following the 2015 program. Conclusions: The NPS MedicineWise programs were associated with reductions in the dispensing rate of high/standard strength PPIs and with an increase in the dispensing rate of low-strength PPIs by June 2016 although a causal relation was not confirmed. Although the rate of high/standard strength PPI prescribing is declining, these formulations still constitute the majority of PPIs used in Australia. Regular interventions to sustain and improve PPI management by GPs may be warranted.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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