Study
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Age (years)/ Sex
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Study design and rating of quality of evidencea
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Institute(s)/ Geography
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Composition
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Comments or additional information
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CHINA
Guan W
N=1099
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median age of 47, only 9 cases below 14 and 153 above 65, predominantly males 58.1%
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Retrospective Cohort study
Rating 3
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552 hospitals distributed in 30 provinces, autonomous regions, and municipalities in mainland
China
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hospitalized as well as from outpatient departments (OPD)
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Composition may represent wider spectrum of the disease from mild to severe.
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CHINA
Chen T
N=274
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median age 62.0 [44.0-70.0] with 53 below 40 and 153 above 60 and 62% were males
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Retrospective case series
Rating 4
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Tongji Hospital
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Only moderate-severe or critically ill patients have been included. OPD cases not included
113/274 died
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Symptoms of those survived are mostly comparable to those died.
Dyspnoea was commoner 62% in those died and only 31% in those recoveredb
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CHINA
Chen J
N=249
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The median age was 51 years old (IQR, 36–64 years),
and 126 (50.6%) were male
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Retrospective cross sectional study
Rating 3
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Shanghai Public Health Clinical Centre (SPHCC)-
hospitalized
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22 (8.8%) -admitted to ICU
215 (86.3%) - were discharged
2 (0.8%) -died
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Has studied the temporal clinical progression ; Median duration of fever was 10 days (95% CI – 8-11 days)
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CHINA
Shou F
N=191
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age 46 to 67, 62% males
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Retrospective Cohort study
Rating 3
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Multicentre
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They represent 50 (26%) ICU admitted cases, and 54 (28%) deaths. Disease severity ranges from general (38%), severe (35%) and critical (28%), thus excluding the milder fraction of the severity spectrum
|
|
CHINA
Sheng F
N=161
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age 45 (IQR 33.5-57)
49.7% males
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Retrospective Cross sectional study
Rating 4
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Changsha Public Health treatment Center (CPHC)
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30 of 161 were taken as severe and the rest were non-severe.
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There was a statistically significant
difference in age between the severe and
non-severe groups (p<0.05), with
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CHINA
Wang D
N=138
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The median age 56 (IQR, 42-68), age range 22-92)
75(73.9%) were men
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Retrospective case series
Rating 3
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Zhongnan Hospital of Wuhan University
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36/138 were admitted ICU and were older (median age, 66 [IQR, 57-78]) than non-ICU patients (median age of 51 [IQR- 37-62]), P<0.001.
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ICU admitted patients were more likely to have pharyngeal pain, dyspnoea, dizziness, abdominal pain and anorexia.
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CHINA
Lui K
N=137
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Age range 20-83, with median 55+/-16.
61/137 (44.5%) were males
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Retrospective cross sectional study
Rating 3
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Respiratory departments of nine tertiary hospitals in Hubei province
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Discharged 44 (32.1%)
Death 16 (11.7%)
Inpatient treatment 77 (56.2%)
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Higher mortality rate likely due to more critical patient cohort involved in the respiratory wards.
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CHINA
Chen N
N=99
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ages from 21-82, with a mean of 55.5 (SD 13.1) and 67% were males
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Retrospective cross sectional study
Rating 4
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Jinyintan Adult Hospital in Wuhan
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11 (11%) - died
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49% of patients had an exposure to seafood market in Huanan.
Article gives data only up to 25 Jan 2020 and outcomes were-11% deaths/ 31% discharged/ rest still hospital
|
CHINA
Zhao X Y
N=91
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median age 46 and 53.8% were male
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Crosssectional study
Rating 4
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hospitalized patients admitted in Jingzhou Central Hospital
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30 (33%)- severely ill
2 (2.2%) – died
61 (67%) - only mild disease
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Outcomes taken when 75 (82.4%) were still in hospital.
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Study
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Age (years)/ Sex
|
Study design and rating of quality of evidencea
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Institute(s)/ Geography
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Composition
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Comments or additional information
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N’lands
Tostmann A
N=90
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aged 21-60 except those 03 above 60 and 82.9% were females
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Cross sectional study
Rating 4
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Radbound university medical centre, Nimegen, The Netherlands
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healthcare workers (HCW), diagnosed with COVID-19 during a screening done on 1,247 mildly symptomatic HCW
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Symptoms analysed from a questioner given but only 803/1,247 Health care workers have responded by filling the questionnaire. They assessed early features of disease and the patients were otherwise healthy.
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INDIA
Gupta N
N=21
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aged 16-73 (mean 40.3) and 66.7% male
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Case series
Rating 4
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Safdarjung Tertiary care Hospital, New Delhi
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None given ICU care and only developed breathlessness and given oxygen
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None had rhinitis or diarrhoea
61.9% of them were frequent travellers to Italy, and rest to other countries.
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EUROPE
Spiteri G
N=38
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ages 2-81 with median 42.6 and 25/38 were males
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Cross sectional study
Rating 4
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Belgium (1), Finland (1), France (12), Germany (16), Italy (3), Russia (2), Spain (2) and Sweden (1)
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Four needed respiratory support one French patient died
|
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KOREA
Kim E S
N=28
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aged 42.6 +/- 13.4 and 53.6% males
|
Case series
Rating 4
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Multicentrec
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6 (21.4%) – needed on oxygen on admission
None - needed mechanical ventilation
22 (78.5%) – had pneumonia
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None of these needed mechanical ventilation.
|
Colanerl M
N=44
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aged 10-94 with median of 67.5 and 28/44 were males
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Cross sectional survey
Rating 4
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single centre in Pavia, Italy
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2 - received sub-intensive care.
3 - admitted to ICU
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Two died and 17 patients had developed severe disease
Data analysed while 23 still in hospital.
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a Quality Rating Scheme for Studies and Other Evidence
- Properly powered and conducted randomized clinical trial; systematic review with meta-analysis
- Well-designed controlled trial without randomization; prospective comparative cohort trial
- Case-control studies; retrospective cohort study
- Case series with or without intervention; cross-sectional study
- Opinion of respective authorities; case reports
b. Features associated with higher morality - ARDS, Type I respiratory failure, acute cardiac injury, heart failure, hypoxic encephalopathy, sepsis, alkalosis, AKI, DIC, hyperkalaemia, shock and acute liver injury were complications frequently observed in those who died than those recovered (n=161). Old age, male sex and presence of comorbidities were associated with higher mortality.
c. Seoul National University Hospital, National Medical Centre and Seoul Medical Centre Incheon Medical Center, Incheon; Seoul National University Bundang Hospital and Armed Forces Capital Hospital, Seongnam; Myongji Hospital, Goyang; Gyeonggi Provincial Medical Center Ansung Hospital, Anseong; Wonkwang University Hospital, Iksan; Chonnam National University Hospital and Chosun University Hospital, Gwangju
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