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Research
Elham Chamani
Birjand University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4615-0034
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Background: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet.
Methods: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.
Results: Metrnl concentration was considerably lower in both UC (85.25±36.55 pg/mL) and CD (76.93±27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups.
Conclusions: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.
Keywords
Meteorin-like, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's disease, Interleukin, Tumor necrosis factor, Adiponectin
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CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 4
Posted 20 Oct, 2020
No community comments so far
Editorial decision: Accept
On 19 Oct, 2020
Review #1 received
Received 18 Oct, 2020
Reviewers invited
Invitations sent on 16 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Editor assigned
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
No comments provided
Editorial decision: Major revision
On 08 Oct, 2020
Review #4 received
Received 06 Oct, 2020
Review #2 received
Received 04 Oct, 2020
Reviewer #4 agreed
On 03 Oct, 2020
Reviewer #3 agreed
On 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Review #3 received
Received 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Reviewers invited
Invitations sent on 28 Sep, 2020
Reviewer #1 agreed
On 28 Sep, 2020
Reviewer #2 agreed
On 28 Sep, 2020
Submission checks complete
On 27 Sep, 2020
Editor invited
On 27 Sep, 2020
No comments provided
Editorial decision: Major revision
On 19 Sep, 2020
Review #4 received
Received 18 Sep, 2020
Review #3 received
Received 14 Sep, 2020
Reviewer #4 agreed
On 10 Sep, 2020
Reviewer #3 agreed
On 10 Sep, 2020
Review #2 received
Received 02 Sep, 2020
Editor assigned
On 01 Sep, 2020
Reviewers invited
Invitations sent on 01 Sep, 2020
Reviewer #1 agreed
On 01 Sep, 2020
Reviewer #2 agreed
On 01 Sep, 2020
Review #1 received
Received 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
No comments provided
Review #2 received
Received 21 Jul, 2020
Editorial decision: Major revision
On 21 Jul, 2020
Review #1 received
Received 18 Jul, 2020
Review #3 received
Received 12 Jul, 2020
Review #4 received
Received 12 Jul, 2020
Reviewer #4 agreed
On 09 Jul, 2020
Reviewer #3 agreed
On 07 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 04 Jul, 2020
Editor assigned
On 03 Jul, 2020
Reviewers invited
Invitations sent on 03 Jul, 2020
First submitted
On 02 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
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A new preprint design is coming!
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See the published version of this preprint at Lipids in Health and Disease.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Elham Chamani
Birjand University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4615-0034
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Lipids in Health and Disease.
Version 4
Posted 20 Oct, 2020
No community comments so far
Editorial decision: Accept
On 19 Oct, 2020
Review #1 received
Received 18 Oct, 2020
Reviewers invited
Invitations sent on 16 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Editor assigned
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
No comments provided
Editorial decision: Major revision
On 08 Oct, 2020
Review #4 received
Received 06 Oct, 2020
Review #2 received
Received 04 Oct, 2020
Reviewer #4 agreed
On 03 Oct, 2020
Reviewer #3 agreed
On 29 Sep, 2020
Review #1 received
Received 29 Sep, 2020
Review #3 received
Received 29 Sep, 2020
Editor assigned
On 28 Sep, 2020
Reviewers invited
Invitations sent on 28 Sep, 2020
Reviewer #1 agreed
On 28 Sep, 2020
Reviewer #2 agreed
On 28 Sep, 2020
Submission checks complete
On 27 Sep, 2020
Editor invited
On 27 Sep, 2020
No comments provided
Editorial decision: Major revision
On 19 Sep, 2020
Review #4 received
Received 18 Sep, 2020
Review #3 received
Received 14 Sep, 2020
Reviewer #4 agreed
On 10 Sep, 2020
Reviewer #3 agreed
On 10 Sep, 2020
Review #2 received
Received 02 Sep, 2020
Editor assigned
On 01 Sep, 2020
Reviewers invited
Invitations sent on 01 Sep, 2020
Reviewer #1 agreed
On 01 Sep, 2020
Reviewer #2 agreed
On 01 Sep, 2020
Review #1 received
Received 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
No comments provided
Review #2 received
Received 21 Jul, 2020
Editorial decision: Major revision
On 21 Jul, 2020
Review #1 received
Received 18 Jul, 2020
Review #3 received
Received 12 Jul, 2020
Review #4 received
Received 12 Jul, 2020
Reviewer #4 agreed
On 09 Jul, 2020
Reviewer #3 agreed
On 07 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 04 Jul, 2020
Editor assigned
On 03 Jul, 2020
Reviewers invited
Invitations sent on 03 Jul, 2020
First submitted
On 02 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Lipids in Health and Disease.
Background: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet.
Methods: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.
Results: Metrnl concentration was considerably lower in both UC (85.25±36.55 pg/mL) and CD (76.93±27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups.
Conclusions: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.
Figure 1
Figure 2
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