Introduction: Among skin diseases, acne represents a special therapeutic challenge because it affects the younger population and significantly affects the quality of life.The chemical composition and biological profile of peloid from Ulcinj (Montenegro) was the subject of our previous research, and the combination of that peloid and medicinal plant tinctures made Peloderm, whose effectiveness in the treatment of acne is tested in this study.
Materials and Methods: A prospective study included 140 subjects diagnosed with acne. They were divided in two groups: Peloderm-treated cohort and Emuslion-treated cohort. The FDA-IGA scale was used to monitor the effectiveness of the treatment.Eighteen-months follow up protocol was applied.
Results: There were significant differences within the examined groups, namely in part of previous antibiotic therapy, body mass index, alcohol consumption and the presence of stress.FDA-IGA score decreases in both cohorts, but more significantly in Peloderm-cohort. Final FDA-IGA score is significantly lower in Peloderm-cohort.
Discussion and Conclusion: Despite official guidelines not recognizing cosmeuticals in acne treatment, Peloderm showed promising results. The formulation's assumed mechanisms of action include reduced sebum secretion, antimicrobial, and anti-inflammatory effects, attributed to peloid and medicinal plant ingredients. Further research are needed.