The aims of this study is to analysis adoption and impacts of conservation agriculture on poverty and resilience to drought in Eastern Ethiopia. Multi-stage sampling method was employed and four districts were randomly selected from Eastern Hararghe Zone. Using cross-sectional survey data collected in 2023 from 430 households, multinomial endogenous switching regression was applied in impact evaluation. The result shows farm experience, education, climatic-socks experience, access to climate information, access to extension, number of oxen, farm size, labor force, livestock and distance to market are determinants of CA adoption in terms of inter-cropping, crop rotation and crop residue retention or mulch practices in its single and combination of practices. Poverty was evaluated based on cost-of-basic-need and resilience to drought is in its index. Results of average treatment effect on treated shows adoption is significantly reduced poverty and increased drought resilience index in the area. The study shows importance role of extension service in adoption of CA practices. Policy implication for these results is that there is a need to encourage extension facilities and awareness to promote better adoption of CA particularly, in its combination. Because, combination of practices increased consumption adopters by 73.3 percent compared to non-adopters, given its significant impact on households’ poverty and resilience to drought in moisture stress area of eastern Ethiopia.