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Research Article
Naira Sahakyan
Yerevan State University
Corresponding Author
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The qualitative and quantitative composition of essential oils (EO) of Ocimum species, cultivated in high altitude Armenian landscape was quite different and the main components of O. basilicum var. purpureum; O. basilicum var. thyrsiflora and O. x citriodorum oils belong to the class of oxygenated monoterpenes. Investigated EOs possess remarkable antioxidant activity. They inhibit the tyrosinase activity, the enzyme responsible not only for the melanin production, but also for various aging-related metabolic processes. Investigated EOs had no any significant effect on catalase at the protein levels, but alter its activity in neuroglial BV-2 different cell lines. Treatment of the neuroglial cell lines with the sub-cytotoxic concentrations of three mentioned EOs influence also the activity of acetyl-CoA oxidase type 1.
Practical Applications The microglial cells play a pivotal role as the neuroprotective agents against neuroinflammation. Different data included in the present article are stating that plant origin substances can play a role of regulators of enzymatic antioxidant capacity of cells. EOs extracted from the Ocimum different cultivars are able to trigger the activity of acetyl-CoA oxidase type 1 (or palmytoil-CoA oxidase type 1), which can serve as a basis of regulation of redox deviation in WT cells. So, it can be suggested them to be applied for the prevention of some processes, which can influence on the aging, as the process of ageing is commonly associated with mitochondrial dysfunction, oxidative stress caused by the increased level of free radical production, dysfunction of the microglia, high blood pressure and so on.
Keywords
Ocimum, essential oil, oxygenated monoterpenes, microglia, palmytoil-CoA oxidase
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Naira Sahakyan
Yerevan State University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Apr, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Molecular Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The qualitative and quantitative composition of essential oils (EO) of Ocimum species, cultivated in high altitude Armenian landscape was quite different and the main components of O. basilicum var. purpureum; O. basilicum var. thyrsiflora and O. x citriodorum oils belong to the class of oxygenated monoterpenes. Investigated EOs possess remarkable antioxidant activity. They inhibit the tyrosinase activity, the enzyme responsible not only for the melanin production, but also for various aging-related metabolic processes. Investigated EOs had no any significant effect on catalase at the protein levels, but alter its activity in neuroglial BV-2 different cell lines. Treatment of the neuroglial cell lines with the sub-cytotoxic concentrations of three mentioned EOs influence also the activity of acetyl-CoA oxidase type 1.
Practical Applications The microglial cells play a pivotal role as the neuroprotective agents against neuroinflammation. Different data included in the present article are stating that plant origin substances can play a role of regulators of enzymatic antioxidant capacity of cells. EOs extracted from the Ocimum different cultivars are able to trigger the activity of acetyl-CoA oxidase type 1 (or palmytoil-CoA oxidase type 1), which can serve as a basis of regulation of redox deviation in WT cells. So, it can be suggested them to be applied for the prevention of some processes, which can influence on the aging, as the process of ageing is commonly associated with mitochondrial dysfunction, oxidative stress caused by the increased level of free radical production, dysfunction of the microglia, high blood pressure and so on.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
The full text of this article is available to read as a PDF.
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