See the published version of this preprint at Cellulose.
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Research Article
Mehran Alavi
Razi University of Kermanshah: Razi University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5691-8326
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The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk fibroin, carrageenan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attaining the advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for theses polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers. Herein, recent advances, present challenges and future perspective for AgNPs incorporated nanocomposites (NCs) are discussed to realize ideal antibacterial activities by exploiting the abundant natural biopolymers.
Keywords
AgNPs, natural polymers, biocompatibility, antibacterial activities, infected chronic wounds, wound dressing
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View the published article at Cellulose.
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Posted 30 Apr, 2021
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Editorial decision: Major revisions
On 02 Jun, 2021
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Received 28 Apr, 2021
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Invitations sent on 27 Apr, 2021
Editor invited
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On 17 Apr, 2021
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On 08 Apr, 2021
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Subject Areas
Cellular & Molecular Neuroscience
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See the published version of this preprint at Cellulose.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Mehran Alavi
Razi University of Kermanshah: Razi University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5691-8326
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Cellulose.
Version 1
Posted 30 Apr, 2021
No community comments so far
Editorial decision: Major revisions
On 02 Jun, 2021
Reviews received
Received 28 Apr, 2021
Reviewers invited
Invitations sent on 27 Apr, 2021
Editor invited
On 20 Apr, 2021
Editor assigned
On 17 Apr, 2021
First submitted
On 08 Apr, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cellular & Molecular Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cellulose.
The aggregation of silver nanoparticles (AgNPs) in colloidal solution and the oxidative cytotoxicity towards human cells are two major hindrances for their thriving medicinal applications. Their incorporation in natural polymers such as cellulose, chitosan, alginate, collagen, gelatin, silk fibroin, carrageenan, hyaluronic acid, keratin and starch may be an alluring alternative strategy to sidestep these complications and attaining the advantageous wound dressings. Biocompatibility, bioavailability, biodegradability, and inherent therapeutic properties known for theses polymers, would accelerate the healing of infected chronic wounds. However, the low thermal stability, mechanical strength, rapid biodegradation, and weak washing resistance properties are some of the limitations for these polymers. Herein, recent advances, present challenges and future perspective for AgNPs incorporated nanocomposites (NCs) are discussed to realize ideal antibacterial activities by exploiting the abundant natural biopolymers.
Figure 1
Figure 2
Figure 3
Figure 4
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