DOI: https://doi.org/10.21203/rs.3.rs-40695/v1
We propose two kinds of compartment models to study the transmission dynamics of COVID-19 virus and to explore the potential impact of the interventions, to disentangle how transmission is affected in different age group. Starting with an SEAIQR model by combining the effect from exposure, asymptomatic and quarantine, then extending the model to an two groups with ages below and above 65 years old, and classify the infectious individuals according to their severity, we focus our analysis on each model with and without vital dynamics. In the models with vital dynamics, we study the dynamical properties including the global stability of the disease free equilibrium and the existence of endemic equilibrium, with respect to the basic reproduction number. Whereas in the models without vital dynamics, we address the final epidemic size rigorously, which is one of the common but difficult questions regarding an epidemic. Finally, using the data of COVID-19 confirmed cases in Canada and Newfoundland & Labrador province, we can parameterize the models to estimate the basic reproduction number and the final epidemic size of disease transmission.
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Competing interests: The authors declare no competing interests.