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Research article
Geum Joon Cho
Korea University College of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6761-0944
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Background: Obstetric hemorrhage is one of the most common causes of obstetrical morbidity and mortality, and transfusion is the most important management for hemorrhage. The aim of our study was to investigate the pre-pregnancy and pregnancy risk factors for peripartum transfusion. Methods: Women who delivered a baby from 2010 to 2014 in Korea and participated in the Korean National Health Screening Program for Infants and Children were included. To analyze pre-pregnant risk factors for peripartum transfusion, an additional analysis was done for women who underwent a National Health Screening Examination within one year before pregnancy, including maternal waist circumference, body mass index, blood pressure, laboratory tests and history of smoking. Multivariable logistic regression analysis was used to estimate the risk factors for peripartum transfusion. Results: Of the total 1,980,126 women who met the inclusion criteria, 36,868 (1.86%) were transfused at peripartum. In a multivariable regression model, the pregnancy risk factors for peripartum transfusion included maternal age above 35 years odds ratio (OR): 1.41; 95% confidence interval (CI): 1.32–1.50, preterm birth (OR: 2.39; 95% CI: 2.15–2.65), and maternal hypertension (OR: 2.49; 95% CI: 2.24–2.77). Pre-pregnancy risk factors including fasting glucose level of more than 126 mg/dL (OR: 1.11; 95% CI: 1.02–1.20), current-smoker status (OR: 1.20; 95% CI: 1.06–1.37), and waist-circumference less than 80 cm (OR: 1.18; 95% CI: 1.06–1.30) were independently associated with peripartum blood transfusion. Conclusions: Several pre-pregnancy and pregnancy risk factors were associated with peripartum blood transfusion. Some identified factors are modifiable before conception, and our study validated peripartum blood transfusion as a form of triage. Keywords: Peripartum, Blood transfusion, Postpartum hemorrhage
Keywords
Peripartum, Blood transfusion, Postpartum hemorrhage
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CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Version 5
Posted 26 Nov, 2019
No community comments so far
Editorial decision: Accept
On 27 Nov, 2019
Editor assigned
On 25 Nov, 2019
Submission checks complete
On 24 Nov, 2019
Editor invited
On 24 Nov, 2019
No comments provided
Submission checks complete
On 21 Nov, 2019
Editorial decision: Minor revision
On 20 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 14 Nov, 2019
Editor assigned
On 07 Nov, 2019
Submission checks complete
On 06 Nov, 2019
Editor invited
On 06 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 05 Nov, 2019
Review #1 received
Received 20 Oct, 2019
Reviewer #1 agreed
On 05 Oct, 2019
Reviewers invited
Invitations sent on 02 Oct, 2019
Editor assigned
On 25 Sep, 2019
Submission checks complete
On 24 Sep, 2019
Editor invited
On 24 Sep, 2019
No comments provided
Editorial decision: Major revision
On 28 Aug, 2019
Review #3 received
Received 27 Aug, 2019
Review #1 received
Received 24 Aug, 2019
Review #2 received
Received 23 Aug, 2019
Reviewer #3 agreed
On 21 Aug, 2019
Editor assigned
On 20 Aug, 2019
Reviewers invited
Invitations sent on 20 Aug, 2019
Reviewer #1 agreed
On 20 Aug, 2019
Reviewer #2 agreed
On 20 Aug, 2019
Submission checks complete
On 19 Aug, 2019
Editor invited
On 19 Aug, 2019
First submitted
On 25 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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A new preprint design is coming!
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See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Geum Joon Cho
Korea University College of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6761-0944
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Version 5
Posted 26 Nov, 2019
No community comments so far
Editorial decision: Accept
On 27 Nov, 2019
Editor assigned
On 25 Nov, 2019
Submission checks complete
On 24 Nov, 2019
Editor invited
On 24 Nov, 2019
No comments provided
Submission checks complete
On 21 Nov, 2019
Editorial decision: Minor revision
On 20 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 14 Nov, 2019
Editor assigned
On 07 Nov, 2019
Submission checks complete
On 06 Nov, 2019
Editor invited
On 06 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 05 Nov, 2019
Review #1 received
Received 20 Oct, 2019
Reviewer #1 agreed
On 05 Oct, 2019
Reviewers invited
Invitations sent on 02 Oct, 2019
Editor assigned
On 25 Sep, 2019
Submission checks complete
On 24 Sep, 2019
Editor invited
On 24 Sep, 2019
No comments provided
Editorial decision: Major revision
On 28 Aug, 2019
Review #3 received
Received 27 Aug, 2019
Review #1 received
Received 24 Aug, 2019
Review #2 received
Received 23 Aug, 2019
Reviewer #3 agreed
On 21 Aug, 2019
Editor assigned
On 20 Aug, 2019
Reviewers invited
Invitations sent on 20 Aug, 2019
Reviewer #1 agreed
On 20 Aug, 2019
Reviewer #2 agreed
On 20 Aug, 2019
Submission checks complete
On 19 Aug, 2019
Editor invited
On 19 Aug, 2019
First submitted
On 25 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background: Obstetric hemorrhage is one of the most common causes of obstetrical morbidity and mortality, and transfusion is the most important management for hemorrhage. The aim of our study was to investigate the pre-pregnancy and pregnancy risk factors for peripartum transfusion. Methods: Women who delivered a baby from 2010 to 2014 in Korea and participated in the Korean National Health Screening Program for Infants and Children were included. To analyze pre-pregnant risk factors for peripartum transfusion, an additional analysis was done for women who underwent a National Health Screening Examination within one year before pregnancy, including maternal waist circumference, body mass index, blood pressure, laboratory tests and history of smoking. Multivariable logistic regression analysis was used to estimate the risk factors for peripartum transfusion. Results: Of the total 1,980,126 women who met the inclusion criteria, 36,868 (1.86%) were transfused at peripartum. In a multivariable regression model, the pregnancy risk factors for peripartum transfusion included maternal age above 35 years odds ratio (OR): 1.41; 95% confidence interval (CI): 1.32–1.50, preterm birth (OR: 2.39; 95% CI: 2.15–2.65), and maternal hypertension (OR: 2.49; 95% CI: 2.24–2.77). Pre-pregnancy risk factors including fasting glucose level of more than 126 mg/dL (OR: 1.11; 95% CI: 1.02–1.20), current-smoker status (OR: 1.20; 95% CI: 1.06–1.37), and waist-circumference less than 80 cm (OR: 1.18; 95% CI: 1.06–1.30) were independently associated with peripartum blood transfusion. Conclusions: Several pre-pregnancy and pregnancy risk factors were associated with peripartum blood transfusion. Some identified factors are modifiable before conception, and our study validated peripartum blood transfusion as a form of triage. Keywords: Peripartum, Blood transfusion, Postpartum hemorrhage
Figure 1
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