This preprint is under consideration at Infectious Diseases of Poverty. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Kai-yu Zhang
the First Hospital of Jilin University
Corresponding Author
License:
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Background
Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of COVID-19 infection in a northern Chinese region and share our local experience.
Methods
A familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) was included for analysis. The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed.
Results
Two family members (Cases 1 and 2) had Hubei exposure history and were admitted to the hospital with a confirmed diagnosis of COVID-19; eight familial members who had contact with them during the incubation period were isolated in a hospital. Finally, the condition of four members (Cases 3, 4, 5, and 6) was as follows. Case 3 had negative SARS-CoV-2 RT-PCR results but was suspected to have COVID-19 because of radiographic abnormalities. Cases 4 and 5 developed COVID-19. Due to positive SARS-CoV-2 RT-PCR results, Case 6 was considered an asymptomatic carrier. In addition, four close contacts did not have evidence of SARS-CoV-2 infection.
Conclusions
Our findings suggest that COVID-19 has infectivity during the incubation period and preventive quarantine is effective for controlling an outbreak of COVID-19 infection.
Keywords
coronavirus disease 2019, family cluster, incubation period, quarantine
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This preprint is under consideration at Infectious Diseases of Poverty. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Kai-yu Zhang
the First Hospital of Jilin University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 13 Jul, 2020
No community comments so far
Submission checks complete
On 10 Jul, 2020
First submitted
On 09 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of COVID-19 infection in a northern Chinese region and share our local experience.
Methods
A familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) was included for analysis. The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed.
Results
Two family members (Cases 1 and 2) had Hubei exposure history and were admitted to the hospital with a confirmed diagnosis of COVID-19; eight familial members who had contact with them during the incubation period were isolated in a hospital. Finally, the condition of four members (Cases 3, 4, 5, and 6) was as follows. Case 3 had negative SARS-CoV-2 RT-PCR results but was suspected to have COVID-19 because of radiographic abnormalities. Cases 4 and 5 developed COVID-19. Due to positive SARS-CoV-2 RT-PCR results, Case 6 was considered an asymptomatic carrier. In addition, four close contacts did not have evidence of SARS-CoV-2 infection.
Conclusions
Our findings suggest that COVID-19 has infectivity during the incubation period and preventive quarantine is effective for controlling an outbreak of COVID-19 infection.
Figure 1
Figure 2
Figure 3
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